抗癫痫药物在孕产妇中的应用  

Administration of Antiepileptic Drugs in Pregnancy with Epilepsy

作　　者：申屠敏[1] 张荣荣[1] 潘琢如[1] 

机构地区：[1]上海第二医科大学新华医院妇产科,上海200092

出　　处：《上海第二医科大学学报》2002年第5期440-442,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：目的探讨抗癫痫药物在癫痫孕产妇中应用的相关因素。　方法对 1985～ 2 0 0 0年 2 6例癫痫孕产妇服药方法、分娩方式、新生儿情况进行回顾性分析 ,并与正常新生儿相比较。　结果 2 6例中孕期坚持服药 8例 ,5例整个孕期不发作。未服药 18例 ,16例发作次数较原来频繁 ,因孕期停药 9例全部出现强直性痉挛性发作。新生儿头围小于正常人群 ,早产 3例 ,宫内发育迟缓 1例 ,畸形 1例。　结论癫痫孕妇应在疾病控制良好后妊娠 ,孕期坚持服药 ,停药或减量易引起癫痫复发。合理选药、单药、低剂量 ,并配以辅助措施 ,可获良好的妊娠结局。Objective To investigate the course of pregnancy and relative factors in pregnant women with epilepsy on administration of AEDs. Methods Data was collected retrospectively from the records of 26 pregnant women with epilepsy from 1985～2000 on the regime of AEDs、 delivery and neonates. Neonatal variables were compared with those of the normal infants. Results Five among 8 patients who received AEDs persistently during pregnancy were seizure free, while 16 among 18 who did not take AEDs had seizures more frequently than before. Nine had a generalized tonic-lonic seizure without AEDs throughout pregnancy. The head circumference of infants were smaller than normal. Three neonates were premature, 1 IUGR,1 malformed. Conclusions It is recommended that optimal seizure control ought to be achieved prior to conception and AEDs Should be administered persistently during pregnancy. Withdrawal or decrease dosage can arouse recurrence. With the lowest effective dosage of a single selected drug together with adjunet methods can have favourable outcomes.

关 键 词：抗癫痫药物 孕产妇 应用 

分 类 号：R714.25[医药卫生—妇产科学]