骨密冲剂对去势大鼠实验性骨质疏松症的影响  

Influence of "Bone Density Granules" on Experimental Osteoporosis in Castrated Rats

作　　者：葛京化[1] 莫文[1] 赵光复[1] 施杞[1] 

机构地区：[1]上海中医药大学附属龙华医院,上海200032

出　　处：《上海中医药大学学报》2002年第3期47-49,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市教委发展基金资助项目 (92D0 8)

摘　　要：为探讨骨密冲剂治疗骨质疏松症 (OP)的疗效与机理 ,3 6只SD大鼠分为 4组 ,正常组 (C)、模型组 (D)、中药组(E)、西药组 (F) ,除C组外 ,其余大鼠行去势手术 ,造成OP模型。术后 4个月开始 ,E、F组分别以骨密冲剂、尼尔雌醇灌胃 ,连续 3个月。观察治疗前后大鼠右股骨抗弯强度 (δf)、全身骨密度 (BMD)及左股骨髁部骨皮质、骨小梁形态。结果 :两用药组δf、BMD及骨组织形态明显好于D组 ,接近C组 ;两用药组间差别无显著性意义。提示骨密冲剂可以替代雌激素治疗OP。In order to explore the therapeutic effect and mechanism of 'Bone Density Granules' in the treatment of osteoporosis (OP),36 SD rats were divided into the four groups:normal group (C),model group (D),Chinese medicine group (E),medication group (F).Except Group C,the rest rats were castrated to be OP models.Four months after castration,Group E and F were respectively fed with 'Bone Density Granules' and Nylestriol continuously for three months,in order to observe the anti bending intensity (δf) of the right femur in the rats,bone density BMD of the whole body and the status of bone cortex and bone trabecula at the ankle of the left femur before and after treatment.The results showed that δf,BMD and bone tissue morphology were obviously better in two medicine groups than in Group D and close to Group C,without significant difference between two medicine groups,indicating that 'Bone Density Granules' can treat OP instead of estrogen.

关 键 词：骨质疏松症 去势动物 骨密冲剂 尼尔雌醇 动物模型 中药 OP 

分 类 号：R285.5[医药卫生—中药学]