高海拔低氧环境对急进青年人血管内皮细胞损害的研究  

Injuries of VEC in healthy youths exposed to various altitude and duration

作　　者：张庆成[1] 汪晓筠[1] 吴康智[1] 司本辉[1] 李积荣[1] 

机构地区：[1]武警上海总队医院一病区,上海201103

出　　处：《武警医学院学报》2002年第3期176-178,共3页Acta Academiae Medicinae CPAPF

摘　　要：目的 :探讨急进不同海拔高度地区 ,不同居住时间 ,低氧环境对血管内皮细胞 (VEC)的损害。方法 :从平原进驻海拔 350 0m和 450 0m地区的第 7天和半年的 1 80名新兵 ,进行循环内皮细胞 (CEC) ,内皮素(ET) ,6 -酮 -前列腺素Fia (6 -kto -PGFia)和血栓素2 (TXB2 )等测定 ,并与平原健康新兵作对照。结果 :海拔 350 0m第 7天组较平原组CEC ,ET ,TXB2 有不同程度各项高 (P <0 0 5 - 0 0 1 ) ,居住半年后上述指标同平原组比较无显著改变 ,海拔 450 0m第 7天组较平原组CEC ,ET ,TXB2 均有显著升高 (P <0 0 1 ) ,半年后上述指标较平原组无明显改变。 6 -kto -PGFia两组第 7天 ,半年均无显著差异。结论 :高海拔低氧环境对VEC的损害主要在早期 ,海拔愈高损害愈明显 。Objective:To investigate the injuries of VEC in healthy youths exposed to various altitude and duration.Methods:High altitude group consisted of 180 healthy soldiers(aged 18-22 years)who exposed to 3500m and 4500m altitude from 1400m for 7 days and 6 months.CEC,ET,TXB 2 and 6-K-PGF ia were measured and compared with control group (1200m) Results:An increase in 6-k-PGF ia was observed on the 7th post exposed day at 3500m altitude( P <0 05),CEC,TXB 2 and ET were stong greater in altitude groups than in control youths( P <0 01).After 6 months,ECE,ET,TXB 2 and 6-K-PGF ia were higher at 3500m than control.It had not a statistical importance( P >0 05).All study data at 4500m altitude for 7 days and 6 months were higher than that of at 3500m( P <0 05).Conclusion:The imbalance of fountion of CEC would result from the injuries of function of VEC in humans under high altitude enviroment.

关 键 词：高海拔低氧环境 青年人 血管内皮细胞 循环内皮细胞 6-酮-前列腺素F ia 血栓素B2 心血管病 

分 类 号：R543[医药卫生—心血管疾病]