正常组织和瘢痕组织中黑色素细胞超微结构的对比研究  

Contrast study on the ultrastructure of melanocytes derived from normal tissue and hypertrophic scar

作　　者：张琳西[1] 郭树忠[1] 王臻[1] 马显杰[1] 黄梅[2] 

机构地区：[1]第四军医大学西京医院整形外科中心,陕西西安710033 [2]第四军医大学基础部中心实验室,陕西西安710033

出　　处：《第四军医大学学报》2002年第18期1713-1715,共3页Journal of the Fourth Military Medical University

基　　金：教育部 1997年留学回国人员启动基金资助

摘　　要：目的　观察正常组织和瘢痕组织中黑色素细胞超微结构的区别 ,探讨在烧 (创 )伤后黑色素细胞在瘢痕形成过程中的作用 .方法　用 JEM2 0 0 0 - EX型透射电子显微镜观察正常组织和瘢痕组织细胞的超微结构 .结果　透射电镜下可见瘢痕组织中黑色素细胞有较多的黑素小体 ,基底层细胞多为黑色素细胞 ,而且角质细胞内有大量的黑素颗粒 .正常组织中基底层黑色素细胞较少 ,且角质细胞嗜取的黑素颗粒也较少 .透射电镜下培养的瘢痕黑素细胞内有大量的 2～ 3期黑素小体 ,而正常黑色素细胞的黑素颗粒较少 .其它细胞器结构两者无明显差别 .结论　烧 (创 )伤后 ,黑色素细胞生存的微环境发生改变 ,引起黑色素细胞增生、迁移、大量分泌黑素 ,促进瘢痕形成及皮肤色素沉着 .AIM To investigate the effects of melanocytes on the hypertrophic scars. METHODS We employed transmission microscope to observe the ultrastructure of melanocytes derived from normal tissues and hypertrophic scars. RE-SULTS We found that, in hypertrophic scars, there was much more melanosome in melanocytes, most of which was located in the basal cell layer and a great amount of melanin in keratinocytes. But in the normal tissue, melanocytes and melanin were much less. CONCLUSION Melanocyte contributes to the formation of scars and pigmentation.

关 键 词：对比研究 黑素细胞 超微结构 肥大性瘢痕 

分 类 号：R619.6[医药卫生—外科学]