原发性慢性肾小球肾炎患者血浆6一Keto一PGF_(la)、TXB_2的变化  

THE INVESTIGATION OF PIASMA 6-KETO-PGFLa AND TXB, IN PRIMARY CIIRONIC GLOMERULON EPHRITIS

作　　者：李一文[1] 陈伯煊 张淑慎[2] 李荣亨[2] 张晓恒[2] 高渝军[2] 

机构地区：[1]浙江中医学院附属医院 [2]重庆医科大学附属第一医院

出　　处：《重庆医药》1991年第5期263-265,共3页

摘　　要：本文用放射免疫方法,测定了48例原发性慢性肾小球肾炎患者血浆6一Keto一PGF_(12)TXB_2的含量及T/6的比值,发现肾炎各型中血浆6一Keto—PGF_(12)含量均明显降低;TXB_2含量在肾病型明显增高,在肾功不全组明显降低。T/6比值在肾功正常各型中明显增高,在肾功不全组无明显改变。结果提示肾炎病变发展过程及,高凝状态的形成中,PCI_2-TXA_2的平衡失调起着重要的作用。为用能增加血浆中PGI_2或减少TXA_2产生的药物来治疗肾炎,提供依据。Plasma concentration of 6-Keto-PGFla(6-K-P) ,TXB2(T)and T/6-K-P were measured by RIA method in 48 cases of chronic glomerulonephritis(CGN)and 30 cases in control group. PiasmaG-K - P decreased in all patients(p<0. 05,0. 01). TXB2 increased significantly in patients with nephrotic syndrome (p<0. 01),but decreased in patients with renal function insufficiency(RFI)(P<0. 01). T/6 - K - P were increased in all cases (p<0. 05)except the RFI patients. The results showed that pathologic progression and hypercoagulation in CGN patients were closely interrelated to the unbalance of PGI2 -TXA2 and increase of T/6 -K -P. In RFI patients, the T/6 -K -P ratio may affect the presence of hypercoagulation of hypocoagulation.

关 键 词：肾小球肾炎 前列环素 血栓素 血浆 

分 类 号：R692.310.2[医药卫生—泌尿科学]