二磷酸盐及NSAIDs对人工关节松动影响的实验研究  

The Effect of BPs or NSAIDs on Aseptic Loosening

作　　者：江红卫[1] 沈铁城[1] 孙俊英[2] 

机构地区：[1]江苏大学附属医院骨科,江苏镇江212001 [2]苏州大学附属第一医院骨科

出　　处：《中国矫形外科杂志》2002年第10期982-983,共2页Orthopedic Journal of China

基　　金：江苏省科技厅资助 (项目编号 :BS2 0 0 0 0 58)

摘　　要：目的 :研究二磷酸盐 (Biphosphonates ,简称BPs) ,及非甾体消炎药 (NSAIDs)对巨噬细胞 (Macrophages ,简称M )介导的骨溶解的影响 ,为临床探索可预防和治疗假体远期松动的药物。方法 :经超高分子量聚乙烯 (UHMWPE)磨屑刺激后的M 培养液中加入45Ca标记的小鼠颅骨及BPs或NSAIDs ,测定颅骨吸收情况 ,并比较分析。结果 :M 培养液中加入BPs后45Ca释放较对照组显著下降 (P <0 .0 1) ;NSAIDs组与对照组之间无显著性差异 (P >0 .0 5 )。结论 :BPs能抑制M 介导的骨溶解过程 ,消炎痛浓度为 10 -6M并不影响骨吸收。试图通过阻断一种或几种骨吸收因子的分泌 ,从而达到抑制骨吸收的设想有待进一步的研究。Objective:To investigate the therapeutic effect of non-steroidal antiphlogistic,biphosphonates on process of bone resorption.Methods:Incubation of radiolabeled calvaria with medium from macrophages exposed to UHMWPE particles and bisphosphonates or NSAIDs for 48 hours.Duplicate 50 ul aliquots of medium were taken from each well and counted for 45 Ca in a scintillation counter.Results:The ratio of calvaria incubated with BPs was 0.3286±0.0049,but the ratio of calvaria incubated with NSAIDs was 0.9654±0.0080.Conclusion:At the therapeutic doses,NSAID have no beneficial effect on the process of aseptic loosening.Certain biphosphonates have a positive effect on process of bone resorption.But this experiment need further research.

关 键 词：人工关节松动 磨屑 二磷酸盐 骨溶解 人工关节 非甾体消炎药 

分 类 号：R318.1[医药卫生—生物医学工程]