盐酸昂丹司琼胃漂浮型缓释片的制备及质量控制  

Preparation and quality control of ondansetron hydrochloride floating sustained release tablets

作　　者：王芳芳[1] 杜蓉[1] 刘祖雄[1] 李晓东[1] 汤韧[1] 王志朝[1] 

机构地区：[1]广州军区武汉总医院,湖北武汉430070

出　　处：《中国药学杂志》2002年第9期678-680,共3页Chinese Pharmaceutical Journal

摘　　要：目的　根据流体动力学平衡控释系统 (HBS)原理研制了盐酸昂丹司琼胃漂浮缓释片 ,并对其体外释放性能进行研究。方法　通过测定盐酸昂丹司琼释放度 ,进行释放机制及影响因素研究。用紫外分光光度法测定主药昂丹司琼的含量。结果　盐酸昂丹司琼胃漂浮缓释片体外释放曲线符合一级动力学方程和Higuchi方程。结论　该制剂有明显缓释作用 ,且制备工艺简单 。OBJECTIVE: To develop the ondansetron hydrochloride floating tablets based on the hydrodynamically balanced drug delivery system(HBS), and evaluate its dissolution in vitro. METHODS: The release mechanism and the influence factors were studied by determining the dissolution. The content of ondansetron in the sustained release tablets was determined by UV spectrophotometry. RESULTS: The release profile of ondansetron hydrochloride from the tablets followed the first-order dynamics equation and Higuchi kinetics equation. CONCLUSION: The prepared sustained-release tablets showed a obviously sustained-release effect, and the preparation process was simple. It is worth further development and application in the clinic.

关 键 词：盐酸昂丹司琼 胃漂浮缓释片 制备方法 质量控制 

分 类 号：R944.9[医药卫生—药剂学]