采用γ照相机考察卡波姆934在狗体内的黏附性  

The Investigation of Bioadhesive Property of Carbomer 934 by Gamma Camera in vivo

作　　者：付劼[1] 孙逊[1] 张志荣[1] 

机构地区：[1]四川大学华西药学院,成都610041

出　　处：《生物医学工程学杂志》2002年第3期423-425,F003,共4页Journal of Biomedical Engineering

基　　金：国家杰出青年科学基金资助项目 ( 3992 5 0 39)

摘　　要：为研究卡波姆 934在狗消化道内的黏附性 ,采用放射性同位素 99m Tc标记卡波姆 934、乙基纤维素 ,用 γ射线闪烁扫描技术观察材料在胃肠道内的排空速度。结果表明 ,与非黏附材料 (乙基纤维素 )相比 ,黏附材料 (卡波姆 934 )在狗消化道各段的排空速度明显较慢。说明在狗体内 ,黏附性材料和非黏附性材料与胃小肠黏膜层的相互作用明显不同 ;卡波姆To study bioadhesive property of carbomer 934 in dog alimentary tract, carbomer 934 and ethylcellulose were radiolabelled with technetium-99m. The gastrointestinal emptying rate of these materials was measured by the technique of gamma scintiscan. The results showed that the empty rate of adhesive material(carbomer 934) was remarkably slower in dog alimentary tract compared to nonadhesive material (ethylcellulose). It is concluded that, in dog, the interaction between gastrointestinal mucus layer and adhesive material or nonadhesive material was significantly different. Carbomer 934 had stronger bioadhesive property in vivo than that of ethylcellulose.

关 键 词：γ照相机 卡波姆934 生物黏附 99mTc γ射线显影 缓控释制剂 乙基纤维素 

分 类 号：R318.08[医药卫生—生物医学工程]