体外反搏对人血压脉动性测量的影响  

Effects of External Counterpulsation on the Pulsatility of Blood Pressure in Human Subjects

作　　者：刘磊[1] 周少春[2] 伍贵富[3] 郑振声[2] 靳亚非 杨世方[2] 詹澄扬[2] 方典秋[2] 钱学贤[1] 

机构地区：[1]第一军医大学珠江医院心内科,广州510280 [2]中山医科大学辅助循环实验室,广州510080 [3]中山医科大学附属第一医院心内科,广州510080

出　　处：《生物医学工程学杂志》2002年第3期467-470,共4页Journal of Biomedical Engineering

基　　金：国家"九.五攻关"资助课题 ( 96 -90 6 -0 2 -12 ) ;中美辅助循环研究基金资助项目 ( 0 40 )

摘　　要：脉动血流对维持正常的血管内皮细胞功能有重要作用 ,本研究拟建立血压脉动性的测量方法 ,并以此评价体外反搏对人血压脉动性的影响。健康青年男性志愿者 8名 ,局麻下穿刺桡动脉 ,送入 4F顶端测压导管至主动脉弓部 ,测量体外反搏前及体外反搏中的血压并计算脉压差、血压脉动指数和血压标准差。结果表明 ,脉压差、血压脉动指数和血压标准差 3个血压脉动性指标分别由反搏前的 47± 5 m m Hg、1.6 4± 0 .11、13.6± 1.5 m m Hg升高到反搏中的 77± 3mm Hg、2 .46± 0 .2 5、19.3± 2 .2 mm Hg,P值均小于 0 .0 5。因此 。Pulsatile blood flow plays an important role in maintaining normal vascular endothelial function. Quantitative measurement of pulsatility of human arterial blood pressure and the influence of enhanced external counterpulsation (EECP) on the pulsatility were investigated in this study. Eight healthy young male volunteers aged 22 to 35 were included. A 4F tip transducer catheter was inserted under local anaesthesia into the radial artery up to the aortic arch. Intraarterial blood pressure was recorded before and during EECP. Blood pulse pressure, pulsatility index (ratio of peak pressure to end diastolic pressure) and standard deviation of blood pressure in 5 cardiac cycle was calculated to evaluate the pulsatility of arterial blood pressure. The results showed that blood pulse pressure, pulsatility index and standard deviation of blood pressure were elevated from 47±5 mmHg, 1.64±0.11 and 13.6±1.5 mmHg to 77±3 mmHg, 2.46±0.25 and 19.3±2.2 mmHg before and during EECP respectively (P<0.05). Decreasing of systolic pressure and increasing of diastolic pressure during counterpulsation were also observed.EECP gives an elevation of pulsatility to human blood pressure.

关 键 词：体外反博 血压 血流脉动性 脉动切应力 

分 类 号：R318.01[医药卫生—生物医学工程]