HJ-1型一氧化氮治疗仪在救治兔海水淹溺肺水肿中的研究  

The Effect of HJ-1 NOHFJV Respirator on Treating Pulmonary Edema Caused by Seawater Drowning

作　　者：樊燕蓉[1] 董文度[1] 何京津[2] 杜立[2] 徐根兴[1] 刘新卷[1] 裴云[1] 傅更峰[1] 马国华[1] 

机构地区：[1]第二军医大学南京军医学院分子医学研究所,南京210099 [2]北京分析仪器厂军事代表室,北京100095

出　　处：《生物医学工程学杂志》2002年第3期526-528,共3页Journal of Biomedical Engineering

摘　　要：采用合作研制的 HJ- 1型一氧化氮高频喷射通气治疗仪用于兔海水淹溺肺水肿的救治。复制兔海水淹溺肺水肿模型 ,将兔随机分为 3组 :海水淹溺肺水肿对照组、4药组 (海水淹溺肺水肿动物用 4种药物和高频喷射通气治疗仪救治 )、NO组 (在 4药组基础上再用 HJ- 1型一氧化氮高频喷射通气治疗仪救治 ) ,用血气分析仪测定Pa O2 、Sa O2 、p H值 ,发现 NO组血氧分压和血氧饱和度比对照组显著提高 ,动物的存活时间大大延长 ,并阻止了海水淹溺肺水肿向海水型呼吸窘迫综合征的转归 。The study was to observe the therapeutic effect of HJ-1 NO-HFJV respirator on treating pulmonary edema caused by seawater drowning. Seawater was infused into the rabbit's lung to establish the animal model of pulmonary edema casued by seawater drowning(PE-SWD). Then the animals were divided into three groups: simple PE-SWD model as control group, treat group(animal model treated with HFJV respirator and four medicines) and HFJV respiratior plus NO group. Pa O 2, Sa O 2 and pH were measured by the blood-gas analyzer. The survival time and seawater drowing-respiratiory distress syndrom(SW-RDS) were observed. The results showed that Pa O 2?Sa O 2 in NO group were remarkably higher than that of PE-SWD control group, and the survival time was longer than that of medicine treated group and the incidence of SW-RDS decreased to zero. We assume that HJ-1 NO-HFJV respirator is efficient on treating pulmonary edema.

关 键 词：HJ-1型一氧化氮治疗仪 海水淹溺 一氧化氮 高频喷射通气 肺水肿 

分 类 号：R649.3[医药卫生—外科学]