米索前列醇两种给药途径预防产后出血的研究  

A Clinical Study on Misoprostol Administered Rectally and Orally in the Prevention of Hemorrhage after Cesarean Section

作　　者：胡文芳[1] 陈迪文[1] 张红芳[1] 

机构地区：[1]黄石市中心医院妇产科,湖北黄石435000

出　　处：《咸宁医学院学报》2002年第3期189-191,共3页Journal of Xianning Medical College

摘　　要：目的观察米索前列醇对剖宫产产后出血的预防效果及副作用。方法将具有高危因素选择性剖宫产的产妇 1 79例 ,随机分为治疗A组、治疗B组和对照组。治疗A组 6 0例 ,麻醉成功后立即用米索前列醇 4 0 0 μg塞入直肠内 ;治疗B组 5 8例 ,在切开子宫时 ,含服米索前列醇 4 0 0 μg ;对照组 6 1例 ,胎儿娩出后立即宫体肌肉注射催产素 2 0IU。对术中、术后 2 4小时内出血量及副作用进行记录。结果两治疗组产妇的产后出血量及产后出血的发生率均低于对照组 ,P均 <0 .0 5。但治疗A组同治疗B组比较差异无显著性意义 (P >0 .0 5 )。治疗B组副作用的发生率明显高于治疗A组和对照组 ,差异有统计学意义 (P <0 .0 5 )。结论米索前列醇能较好地预防剖宫产产后出血 ,且用药经济、方便。但为了进一步降低副作用的发生率 ,使用药更安全 。Objective To observe the effect of misoprostol on reduction of postpartum bleeding in cesarean section and its side effections.Methods Ceserotomies were performed on 179 cases of parturient women with high risk factors.The cases were randomly devided into three groups:Cure group A (n=60),400μg misoprostol was given rectally when anesthesia was finished;Cure group B(n=58),400μg misoprostol was given orally when the uterine was cut;Control group(n=61),20IU oxytocin was injected into uterine muscle immediately after delivery of baby.The amounts of bleeding within 24 hours after delivery were measured and the side effections were recorded.Results The amounts of bleeding within 2 hours and at 2 to 24 hours after delivery and the incidence of postpartum hemorrage in cure group A and B were lower than those in control group (P&lt;0.05).The amounts of bleeding after delivery or the incidence of postpartum hemorrage between the cure group A and B was no difference(P&gt;0.05).The incidence of side effections was higher in cure group A than that in cure group B (P&lt;0.05).Conclusions Misoprostol is more effective in reduction of postartum bleeding than oxytocin.But it should be used rectally in order to reduce the incidence of side effects.

关 键 词：米索前列醇 给药途径 预防 产后出血 研究 

分 类 号：R714.461[医药卫生—妇产科学]