聚羟基丙酸乙酸膜的降解  

Degradation of PLGA Film

作　　者：唐智荣[1] 黄虹[2] 饶炬[1] 程树军[1] 

机构地区：[1]华东理工大学材料科学研究所,上海200237 [2]上海信息技术学院,上海200331

出　　处：《华东理工大学学报（自然科学版）》2002年第4期383-385,共3页Journal of East China University of Science and Technology

摘　　要：以 GPC、NMR及 DSC等分析方法 ,研究了聚羟基丙酸乙酸 (PLGA)降解过程中 ,相对分子质量及其分布、吸水率、失重及玻璃化温度的变化 ,并探讨了 PLGA的体外降解机理。结果表明 :降解温度高于 1 0°C时 ,PLGA进行均相降解 ;温度低于 1 0°C时 。Poly(lactic acid co glycolic acid), a biodegradable material, was widely applied in the field of system. In this paper, changes of molecular weight, molecular weight distribution, water absorption, polymer weight loss and glass transition temperature of PLGA during the degradation process were studied, and the degradation mechanism in vitro was also discussed. The results show that when the temperature is higher than 10°C, the PLGA film processes homogeneous degradation; on the contrary, it processes heterogeneous degradation.

关 键 词：聚羟基丙酸乙酸膜 药物控制释放 玻璃化温度 降解机理 生物降解型聚酯 生物材料 

分 类 号：R318.08[医药卫生—生物医学工程] R944.9[医药卫生—基础医学]