一种新的二维平板分叉流槽的设计  

A NEW DESIGNED TWO-DIMENSIONAL BIFURCATION PARALLEL-PLATE FLOW CHAMBER

作　　者：胡嘉[1] 胡江[1] 陶祖莱[1] 

机构地区：[1]中国科学院力学研究所国家微重力实验室,北京100080

出　　处：《医用生物力学》2002年第3期129-133,共5页Journal of Medical Biomechanics

基　　金：国家自然科学基金重点项目 (19732 0 0 3)

摘　　要：目的　解决平行平板流槽每次实验只能观测壁面培养细胞受一种剪应力作用的问题。方法　作者在平行平板流槽的基础上 ,首次提出了一种改进后的流槽———二维平板分叉流槽。通过数值模拟 ,给出了流体作定常流动时 ,流速和壁面剪应力的分布。结果　结果发现 ,利用这种二维平板分叉流槽可以研究壁面培养的细胞在不同大小剪应力作用下的力学行为。结论　该研究结果为流槽的合理设计和使用 。Objective In order to solve the problem that only one kind of shear stress values could be observed during each parallel-plate flow chamber (PPFC) experiment, a kind of new PPFC - Two-Dimensional Bifurcation Parallel-Plate Flow Chamber (TDBPPFC) is proposed. Methods The distributions of the velocities inside and the shear stresses at the bottom of the chamber are given by computational simulation with laminar flow in the TDBPPFC. Results The results show that the mechanical behaviors of cultured cells undergoing the shear stresses with various values may be simultaneously observed by using this kind of new flow chamber. Conclusion These results possessed practical importance in optimum design and rational use of the TDBPPFC. And it was also helpful in analyzing the mechanical behavior of the cells and in discussing the effects of the shear stress distribution on the cells in the TDBPPFC.

关 键 词：二维平板分叉流槽 剪应力 剪应力梯度 内皮细胞 细胞生长 

分 类 号：R318.01[医药卫生—生物医学工程] R329.2[医药卫生—基础医学]