中药硇砂提取液裸小鼠肿瘤内注射治疗肝癌的实验研究  

An experimental study of Chinese traditional medicine Sal-Ammoniae extract liquid by intra-tumor injection to treat liver cancer on naked mice

作　　者：孙铭[1] 朱争艳[1] 方淑昌[1] 周立波[1] 赵均铭[1] 楮建新[1] 杜智[1] 宋继昌[1] 

机构地区：[1]天津市第三中心医院肝胆疾病研究所,300170

出　　处：《肿瘤防治研究》2002年第5期365-366,372,共3页Cancer Research on Prevention and Treatment

基　　金：天津市科委重点项目<肝癌综合治疗研究>子课题 (0 0 3112 311)

摘　　要：目的　通过对矿物中药硇砂成份分析和有效提取 ,制备出A、N和Z剂进行动物肝癌治疗研究。方法　体外以人 772 1肝癌细胞系进行不同药物成份及浓度杀癌细胞效果评价 ;体内用裸小鼠 772 1肝癌模型肿瘤内注射治疗效果观察。结果　体外与抗癌药物表阿霉素、无水乙醇及冰醋酸等比较 ,所筛选有效成分均优于或相当于对照 ,且与药物浓度相关。体内实验可使肿瘤体积显著缩小 ,直至瘤块坏死吸收消失。结论　抗肿瘤药硇砂有效成分提取剂在肝癌动物模型治疗上 ,效果优于无水乙醇 ,是肝癌局部治疗一种可供选择方法。Objective By means of component analysis and valid extraction of Chinese traditional anti\|tumor mineral drug Sal\|Ammoniae, we prepared A?N and Z agents to offer a remedy to liver cancer by intra\|tumor injection . Methods In vitro we adopted L7721 liver cancer cells strains to conduct the cancer cell killing effect evaluation; In vivo naked rice loaded with L7721 cancer strain were used to appraise the anticancer effect by means of intra\|tumor injection.Results In vitro experiment showed our agents have the same or even better anticancer effect comparing with pharmorubicin or absolute alcohol ,also having significant dosage\|effect correlative relationships; In vivo all agents notably decreased the volume of the tumor, even led to completely necrosis and vanish of the mass. Conclusion To be an anti\|tumor drug sal\|Ammoniae active constituent extraction liquid have obviously cure effect on liver cancer of the model animals, even superior to absolute alcohol that were widely used in clinical practice.

关 键 词：硇砂提取液 硇砂 肝癌 瘤内注射 中药疗法 疗效 

分 类 号：R273.57[医药卫生—中西医结合] R285[医药卫生—中医肿瘤科]