职业接触苯乙烯的生物限值研究  

Study on the Biological Limit Values for Occupational Exposure to Styrene

作　　者：沈波 沈惠麒[2] 程怀民 郑鹏飞 陈锦[3] 程生英 

机构地区：[1]福州市晋安区卫生防疫站,福建350014 [2]北京大学公共卫生学院,北京100083 [3]福建医科大学公共卫生学院,福州350004

出　　处：《海峡预防医学杂志》2002年第4期4-6,共3页Strait Journal of Preventive Medicine

基　　金：卫生部卫生标准"职业接触苯乙烯生物接触限值"研制课题(1 0 - 99- 0 2 1 )

摘　　要：[目的 ]研究职业接触苯乙烯的生物限值。 [方法 ]高效液相色谱法测定苯乙烯作业工人班前、班后尿中苯乙醛酸 (PGA)和苯乙醇酸 (MA)的含量 ,监测工人 8h苯乙烯的接触水平 ,同时研究两者的相关性。 [结果 ]尿中的 PGA和 MA浓度与苯乙烯的接触量有明显的剂量—反应关系。根据作业场所空气中苯乙烯的国家卫生标准 ,按回归方程推导出职业接触苯乙烯的生物限值。 [结论 ]对职业接触苯乙烯的生物限值提出的推荐值 :工作班末 MA为 2 2 0 mmo1/ mol肌酐或 30 0 mg/ g肌酐 ,下一班前为 88mmo1/ mol肌酐或 12 0 mg/ g肌酐 ;PGA班末为 7mmo1/ mol肌酐或 10 0 mg/ g肌酐 ,下一班前为 30 mmo1/ mol肌酐或 4 0 mg/ g肌酐。To study the biological limit values for occupational exposure to styrene. To detect the concentrations of phenylacetaldehyde acid (PGA) and mandelic acid (MA) in the urine of the workers before and after working shift by high performance liquid chromatography (HPLC) and monitor the exposure level to the styrene in 8h. The relationship between styrene exposure level and concentration of PGA and MA in urine was analyzed. There was a dose effect relationship between styrene exposure level and concentration of PGA and MA in the urine. The biological limit values for occupational exposure was calculated by the regression equation according to the national hygiene standard of styrene in workplace. [Conclusion] The biological limit values for occupational exposure to styrene are recommended as follows: 220 mmo1/mol or 300 mg/g creatinine for MA after shift, and 88 mmo1/mol or 120 mg/g creatinine for MA before shift; 7 mmo1/mol or 100 mg/g creatinine for PGA after shift, and 30 mmo1/mol or 40 mg/g creatinine for PGA before shift.

关 键 词：苯乙烯 生物接触限值 职业中毒 苯乙醛酸 苯乙醇酸 高效液相色谱分析法 苯中毒 

分 类 号：R135.12[医药卫生—劳动卫生]