中药912胶囊及其不同组分对急性感染患者甲襞微循环影响作用的临床研究  

The effect of Chinese herbal 912 capsule and it′s different ingredients to the nail microcirculation in the patients with acute infectious disease

作　　者：薄世宁[1] 梁琪[1] 张淑文[1] 王宝恩[1] 

机构地区：[1]首都医科大学附属北京友谊医院感染暨急救医学内科

出　　处：《临床和实验医学杂志》2002年第2期73-76,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的　从微循环角度探讨 912胶囊及其不同组分对急性感染患者的治疗作用 ,以深入探讨其作用机理及作用靶位。方法　采取随机、双盲、安慰剂对照原则 ,选取 97例急性感染患者 ,随机分为 912胶囊组 (912全方由黄芪和祛瘀类药物组成 )、黄芪组、祛瘀组以及安慰剂组 ,四组入选病例数依次为 2 5例、 2 4例、 2 3例、 2 5例。将口服药物制备成胶囊 ,胶囊颜色、重量、口服剂量各组一致。各组均在治疗前、治疗后 48小时及第七天行甲襞微循环检查。结果和结论　急性感染患者治疗前微循环血流速度减慢、具有红细胞中度或重度聚集现象 ;黄芪对改善血流速度明显 ,而祛瘀类药物则具有降低红细胞聚集性的作用 ,912组疗效优于黄芪。Objectives Acute infectious diseases are the most commonest causes leading to systemic inflammatory response syndrome(SIRS)and multiple organ dysfunction syndrome(MODS) The disorders of hemorrheology play an important role during the process Methods A randomized?double-blinded?placebo-controlled clinical trial was conducted ninety seven patients were randomly divided into 4 groups- 912 group(25 cases)?HuangQi group(24 cases) and sludge-eliminating group(23 cases)? placebo-controlled group(25 cases) All drugs were produced into a model of capsule which was same color?same weight and same dose among the four different groups Nail microcirculation(NMC)were checked before the treatment and 48 hours?the seventh day after treatment Results and Conclusions During the process of acute infection, feature of the nail microcirculation is manifested by lower blood velocity and increased aggregation of erythrocyte 912 capsule,can markedly increase the blood velocity of microcirculation During the course,HuangQi,can increase the blood velocity in the early course of acute infection And sludge-eliminating drugs,can decrease the aggregation of erythrocyte As to the effect of increasing blood velocity and decreasing the aggregation of erythrocyte ,the whole compound of 912 capsule is prior to HuangQi and sludge-eliminating drugs singlely

关 键 词：中药912胶囊 急性感染 甲襞微循环 作用机理 活血化瘀 

分 类 号：R278[医药卫生—中医学]