心肌肌动蛋白在青壮年猝死综合征患者死因诊断中的应用  

IMMUNOHISTOCHEMICAL STUDY OF ACTIN IN MYOCARDIUM OF SUDDEN MANHOOD DEATH SYNDROME

作　　者：于家华[1] 姜英[1] 刘盾[1] 李瑞琴[2] 盛树青[2] 

机构地区：[1]扬州大学医学院病理学教研室 [2]扬州大学医学院形态学实验室

出　　处：《江苏临床医学杂志》2002年第4期337-339,共3页Journal of Jiangsu Clinical Medicine

摘　　要：目的 :探讨心肌细胞内肌动蛋白在青壮年猝死综合征死因诊断方面的价值。方法 :应用免疫组化LSAB法对 16例青壮年猝死综合征病例进行心肌细胞内肌动蛋白的研究 ,并以 15例冠心病猝死病例和 15例非心性死亡病例分别作阴性和阳性对照。结果 :16例青壮年猝死综合征病例中 ,有 13例心肌细胞内肌动蛋白明显缺失 ,2例轻度缺失 ,1例无缺失。 15例冠心病猝死阴性对照组心肌细胞内肌动蛋白均明显缺失。 15例非心性死亡阳性对照组心肌细胞内肌动蛋白均无缺失。结论 :心肌细胞内肌动蛋白免疫组化检测可作为青壮年猝死综合征死因诊断的指标。Objective:To study the value of diagnosis for the cause of the sudden manhood death syndrome(SMDS).Methods:Actin in myocardium from 16 cases of SMDS and control groups were detected by the immunohistochemical technique(LSAB method).Negative control group included 15 cases of sudden coronary death(SCD) and positive control group included 15 cases of non-cardiac death.Results:There were marked decrease of actin in myocardium from 13 cases of SMDS, slight decrease in 2 cases,and no decrease in 1 case of SMDS.The marked decrease of actin was observed in the negative control group,and there was no decrease of actin in the positive control group.Conclusion:The immunohistochemical detection of actin of in myocardium may be an index approach for diagnoseing the causes of death of SMDS.

关 键 词：心肌肌动蛋白 死因诊断 青壮年猝死综合征 免疫组化 LSAB法 

分 类 号：R541[医药卫生—心血管疾病]