超排卵治疗对机体免疫和生殖内分泌的影响  

Impact of superovulation on immunity and reproductive endocrine in women with infertility

作　　者：王庆一[1] 杨桂艳[1] 

机构地区：[1]广东省珠海市妇幼保健院妇科,519000

出　　处：《广东医学》2002年第9期919-920,共2页Guangdong Medical Journal

基　　金：本课题为广东省医药卫生青年科学研究基金资助项目(编号:B1998151)

摘　　要：目的 探讨促性腺激素对生殖内分泌-免疫系统的影响。方法 测定52例不孕症患者超排卵治疗前后卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）、抗卵巢抗体（AOA）、抗磷脂抗体（APA）、抗核抗体（ANA）、抗双链DNA抗体（ds-DNA）的变化。结果 治疗后FSH,LH,E2较治疗前无显著性变化（P>0.05）,治疗后8例患者出现AOA,2例出现ds-DNA。结论 超排卵不影响血清FSH,LH,E2水平,可能对机体的免疫功能有所影响,但无明显临床表现。Objective To determine whether superovulation could result in production of autoantibodies or have an effect on reproductive endocrine in women with infertility. Methods 52 women undergoing superovulation with HMG/HCG entered this study, serum antiovarian antibody (AOA) , antiphospholipid antibody (APA) , antinuclear antibody (ANA) , ds - DNA and reproductive hormone FSH, LH, E2 were measured before and after HMG/HCG treatment. Results After HMG/HCG treatment, 8 were AOA - positive and 2 were ds - DNA - positive. There were no significant difference in FSH, LH and E2 before and after treatment(P>0.05). Conclusion Large dose gonadotropin may have adverse effect on immune system but have no impact on reproductive hormone secretion.

关 键 词：治疗 机体免疫 生殖内分泌 超排卵 自身免疫性抗体 不孕症 助孕 促性腺激素 

分 类 号：R711.6[医药卫生—妇产科学] R977.12[医药卫生—临床医学]