肉桂超细微粉的粉体特征及体外透皮作用的研究  

Characteristics of particles of Cortex cinnamomi Ultra-fine powder and its transdermal effect in vitro

作　　者：赵浩如[1] 杨永刚[1] 何煜 刘惠娟[3] 

机构地区：[1]中国药科大学中药制剂教研室,江苏南京210038 [2]济南倍力粉技术工程有限公司,山东济南250100 [3]中国药科大学生药药用植物教研室,江苏南京210038

出　　处：《中成药》2002年第9期653-656,共4页Chinese Traditional Patent Medicine

摘　　要：目的 :了解超细微粉技术在中药外用散剂中的应用前景。方法 :观察肉桂超细微粉细胞形态学特征 ,并与普通粉末进行比较 ;测定肉桂超细微粉粉体的物理参数 ;用改进的Franz扩散池进行散剂大鼠皮肤渗透实验 ,测定肉桂主要有效成分肉桂醛的透过量。结果 :肉桂超细微粉的粒径小 (D50 =12 .72 μm) ,肉桂粉末的特征显微结构不明显。全肉桂超微粉具有较好的透皮效果 ,肉桂醛透过量与时间成线性关系 ,渗透开始后 1h的时间内 ,渗透速度最大 (0 .2 5mg/cm2 /h) ,此后渗透速度变缓 ,8h累积透过率为 1.0mg/cm2 ;加入稀释剂制成的散剂的透过量相应降低。结论Objective: To investigate the prospect of applying technology of ultra fine powder (UFP) to TCM powders for external use. Methods: The morphocytology between UFP of Cortex cinnamomi , compared with its common powder, was observed; physical parameters of the UFP particles and the penetrating amount of cinnamaldehyde, through rat skin in vitro was determined with an improved Franz diffuse cell. Results: The diameter of the UFP particles detected was small (D 50 =12.72μm). and a typical microscopic characters of Cortex cinnamomi powder was not observed. The Cortex cinnamomi UFP have good transdermal effects. There existed the linear relationship between penetrating amount of cinnamaldehyde and penetrating time. The highest penetrating rate (0.25mg/cm 2/h) was within the first hour in the beginning, and then the rate became lower and sustained. The accumulating transdermal amount of the UFP was 1.0mg/cm 2 totally in 8 hours. Conclusion: It indicated that UFP might have a fine respect, applied in cosmetic or drug preparations for external use.

关 键 词：肉桂 超细微粉 体外透皮 中药 外用散剂 

分 类 号：R282.4[医药卫生—中药学] R285[医药卫生—中医学]