愈痫灵颗粒剂中3种挥发油的提取及β-环糊精包合物的制备研究  

Extraction of three kinds of volatile oil and preparation of β-CYD inclusion compound of Yuxianling Granules

作　　者：何群[1] 王净净[1] 钟艳[1] 顾星[1] 李振光[1] 段祖珍[1] 

机构地区：[1]湖南中医学院,湖南长沙410007

出　　处：《中成药》2002年第9期660-662,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :为探讨愈痫灵颗粒剂 3种挥发油的混合提取及包合最佳工艺路线。方法 :采用正交设计实验 ,以挥发油重量为评价提取工艺指标 ,以包合物收率、油转移率、油包合率为评价包合工艺指标。结果 :提取最优工艺条件是 :药材混合加 5倍量水 ,浸泡 90min ,加热至沸腾回流 4h ;包合适宜用研磨法 ,较好的工艺条件是 :β 环糊精与挥发油按 8∶1投料 ,加2倍量水研磨 30min。结论 :按上述工艺条件提取、包合本制剂中这Objective:To specify optimize condition of process for mixture extraction of three kinds of volatile oil and preparation of β CYD inclusion compound of Yuxianling Granules.Methods: Taking weight of volatile oil to evaluate the extraction process and percentage recovery of inclusion compound, transfer rate of oil, inclusion rate of oil to evaluate the inclusion process. Orthogonal design was applied. Results: The optimum extraction condition was to add five times amount of water into the mixture of crude drugs, to soak for 90 min, to heat up to boiling and reflux 4h. The trituration method is suitable for the productive preparation of inclusion compound, the optimum inclusion condition was β CYD: Volatile oil in proportion as 8∶1 was mixed, adding two times amount of water into the mixture and trituration 30 min.Conclusions: Above condition of process was the most rational in extraction and inclusion of three kinds of volatile oil.

关 键 词：Β-环糊精包合物 愈痫灵颗粒剂 挥发油 提取 包合 正交设计实验 川芎 牡丹皮 石菖蒲 

分 类 号：R283[医药卫生—中药学] R284.2[医药卫生—中医学]