大剂量^(153)Sm-EDTMP联合帕米磷酸二钠治疗骨转移癌止痛效果观察  

^（153）Sm-EDTMP combined pamidronate disodium in treatment bone metastasis

作　　者：黄带发[1] 张丽辉[1] 易侠[1] 王治国[1] 

机构地区：[1]解放军沈阳军区总医院,辽宁沈阳110016

出　　处：《中国组织工程研究》2000年第14期26-27,共2页Chinese Journal of Tissue Engineering Research

摘　　要：目的 探讨大剂量１５３Ｓｍ－ＥＤＴＭＰ联合帕米磷酸二钠治疗骨转移癌的止痛效果。方法 ５１ 例确诊骨转移癌病人分成２组，其中治疗组３１例：应用１５３Ｓｍ－ＥＤＴＭＰ１８５０ ｍＢｑ静注１次，帕米磷酸二钠３０ｍｇ＋生理盐水５００ｍｌ，静滴，１／ｄ，连用３ｄ；对照组２０例：单用１５３Ｓｍ－ＥＤＴＭＰ１８５０ｍＢｑ治疗；每 ３～５个月重复 １次。结果联合治疗组病人生存时间延长：治疗组：（４５． ４ ± １０． ０）周，对照组（３７．４±１０．０）周（Ｐ＜０．０１）。治疗组止痛有效率１００％，对照组９０％（Ｐ＞０．０５）。两组副反应发生率无显著差异，未出现治疗相关死亡。结论联合治疗是有效的和安全的。Objective To evaluate the effctive of 153Sm-EDTMP with Pamidronate disodium in treatment bone metastasis patients. Method Patients of 5l were divided into two groups. In treatment group: 153Sm-EDTMP 1850mBq injected once time and Pamidronate disodium 30 mg, constant infusion drip once day, three times, In control group: 153Sm-EDTMP 1850 mBq injected once only. This treatment repeated every 3 ～5 monthe. Result The lifetime of patients n treatment group(45. 5 ± 10. 0w) is longer than in control group(37. 4 ± 10. 0w), P < 0. 01. But side effect in two groups has no significant difference. Conclusion 153Sm-EDTMP with Pamidronate disodium are effective and safe in treatment bone metastasis.

关 键 词：153SM-EDTMP 帕米磷酸二钠 骨转移癌 

分 类 号：R4[医药卫生—临床医学]