Improvement for the Synthesis of Centchroman  

作　　者：季小慎[1,2] 苗奕[1,2] 刘延 金涛[1,2] 宋鹏 

机构地区：[1]空军总医院药理科药物化学室 [2]北京市医药药品公司

出　　处：《Journal of Chinese Pharmaceutical Sciences》1998年第2期13-15,共3页中国药学（英文版）

摘　　要：\ The synthesis of centchroman has been improved. The hydrogenation under high pressure and configuration transformation in the reported route were omitted. The trans isomer was obtained in highly stereo selective Friedel Crafts alkylation and centchroman was obtained by five steps with the overall yield of 40%.Ｃｅｎｔｃｈｒｏｍａｎ是一新型非甾体女用口服避孕药，我们对其合成路线进行了改进。其中在ＦｒｉｅｄｅｌＣｒａｆｔｓ烷基化反应中高选择性地获得反式异构体，从而避免了文献报道中的高压氢化和构型转化两个反应单元。共五步反应得到最终产物。收率达４０％。

关 键 词：CENTCHROMAN Total synthesis 

分 类 号：R9[医药卫生—药学]