臭氧对小鼠开阔行为、被动回避反应、脑区M受体和LPO的影响  

Influences of ozone on open-field behavior, passiveavoidance response, muscarinic receptors and LPO in mice

作　　者：潘思源[1] 

机构地区：[1]北京中医药大学药理教研室

出　　处：《中国药理学通报》1994年第5期355-358,共4页Chinese Pharmacological Bulletin

摘　　要：幼年小鼠吸入臭氧（０．９ＰＰｍ）１２ｈ·ｄ－１连续３０ｄ后体重减轻。并减弱了东莨菪碱（Ｓｃｏｐ）对行为的作用，但增加了小鼠对Ｓｃｏｐ致记忆障碍的敏感性。受体结合实验显示、吸臭氧小鼠的额叶皮层和海马Ｍ受体数增加，纹状体Ｍ受体数减少。全脑过氧化脂质（ＬＰＯ）减少４７％，皮层ＬＰＯ减少４６％。Young mice were exposed to an ozone environment from 20:00 to 08:00 for 30d. At 08:00,the content of ozone resulted from ultra-violet lamp was 0.9 ppm. Scopolamine(Scop 0.1mg·kg-1)was given ip 15 min before training in stepthrough and step-down tests or the first behavioral test in open field. The behavior and memory in mice were not influenced by ozone. However the effects of Scop on open-field behavior and avoidance memory were respectively less and more sensitive than those in normal mice. The binding slies of[3H]QNB increased in the frontal cortex and hippocampus,but decreased in the striatum region in the mice treated with ozone. The concentrations of lipid peroxidation measured by thiobarbituric acid in the mice exposed to ozone reduced 47%in whole brain and 46% in the frontal cortex.

关 键 词：开阔行为 被动回避反应 记忆 臭氧 过氧化脂质 东莨菪碱 毒蕈碱受体 

分 类 号：R96[医药卫生—药理学]