白芍总甙的抗惊厥作用  

Anticonvulsant action of total glucosides of paeony root

作　　者：张艳[1] 明亮[1] 王瑜[1] 马红星 马传庚[1] 徐叔云[1] 

机构地区：[1]安徽医科大学药理教研室,合肥经济技术学院医院

出　　处：《中国药理学通报》1994年第5期372-374,共3页Chinese Pharmacological Bulletin

摘　　要：采用最大电休克发作（ＭＥＳ）法、士的宁惊厥法和戊血氮最小阈发作（ＭＥＴ）法，观察白芍总甙（ＴＧＰ）对动物惊厥的影响。实验结果表明，ＴＧＰ（２０～８０ｍｇ·ｋｇ－１·ｄ－１，ｉｐ和ｉｇ×３ｄ）呈剂量依赖性对抗小鼠的ＭＥＳ。ＴＧＰ（６０～１００ｍｇ·ｋｇ－１·ｄ－１，ｉｐ）能对抗士的宁引起的小鼠和大鼠的惊厥。ＴＧＰ（４０～８０ｍｓ·ｋｇ－１·ｄ－１，ｉｐ）对小鼠的ＭＥＴ无影响。ＴＧＰ（４０～８０ｍｇ·ｋｇ－１·ｄ－１，ｉｐ）对小鼠ＭＥＳ的作用高峰时间在０．５～１．５ｈ之间。The anticonvulsant action of Total Glucosides of Paeony Root(TGP) was investigated in Maximal electroshock Seizure(MES),strychinine-induced convulsion and Metrazol Minimal threshold Seizure(MET), respectively. The results showed that TGP(20￣80 mg·kg-1·d-1, ip and ig×3d)had a dose-dependent protective effect against MES in mice and TGP (60￣100mg·kg-1· d- 1,ip)also had an antagonism to strychinine-induced convulsion in botn mice and rats, but it(40￣80 mg·kg-1,ip)did not influence MET in mice.In addition,the Peak time of anticonvulsant action of TGP(40￣80 mg·kg-1, ip)against MES in mice was at 0.5￣1.5 h after administration of this drug.

关 键 词：白芍总甙 最大电休克发作 士的宁 惊厥 戊四氮最小阈发作 

分 类 号：R96[医药卫生—药理学]