肺炎链球菌耐药状况分析  

Analysis of Antimicrobial Resistance of Streptococcus Pneumoniae Isolated From Children in Guangzhou Area

作　　者：曾淑珍[1] 牟一坤[2] 陈林珍[1] 方爱姿[1] 

机构地区：[1]广东药学院附属第一医院,广东广州510080 [2]中山大学附属第三医院,广东广州510630

出　　处：《中国医疗前沿》2007年第22期29-30,共2页China Healthcare Innovation

基　　金：广东省医学科研立项课题(A2005515)。

摘　　要：目的了解肺炎链球菌对常用抗生素的耐药情况,以指导临床合理用药。方法对2005年3月～2006年2月来院就诊的呼吸道感染患儿的鼻咽分泌物、痰进行细菌培养,用K-B纸片及E-test法对分离株进行药物敏感试验。结果分离出肺炎链球菌51株,肺炎链球菌对青霉素的耐药率为50.98%,对其他抗生素耐药率为头孢呋辛35.29%、红霉素66.67%、克林霉素64.71%、四环素78.43%,复方磺胺甲基异(?)唑68.63%。而对阿莫西林/克拉维酸耐药率仅为7.84%、头孢曲松11.76%,有很好的敏感性。PNSSP株多重耐药率及对其他β-内酰胺类抗生素如头孢呋辛、红霉素、克林霉素、复方磺胺甲基异(?)唑耐药率明显高于PSSP株。结论儿童呼吸道感染的肺炎链球菌耐药形势严峻。Objective To investigate the situation of antibiotic resistance of Streptococcus pneumoniae(Sp)clinical isolates from children in Guangzhou ares.Methods The authors cultured,isolated and identified the Sp from nasopharyngeal secretion,sputum of patients who visited our hospital for respiratory tract infection between 2005 and 2006.K-B disc diffusion and E-test for antibiotic susceptibility were performed for these clinical isolates.Results Totally 51 strains of Sp were respectively isolated from nasopharyngeal secretions in the hospital.For Sp strains,the rates of resistance to penicillin,amoxicillin/clavulanic acid,ceftriaxone,cefuroxime,erythromycin,clindamycin,tetracycline,sulfamethoxazole/trimethoprim(SMZ/TMP)were 50.98%, 7.84%,11.76%,35.29%,66.67%,64.71%,78.43%,68.63%,respectively.The penicillin non-susceptible Sp(PNSSP)isolates showed higher rates of resistance to other antimicrobial agents such as otherβ-lactam antimicrobial agents,erythromycin, clindamycin-,and SMZ/TMP than those of penicillin susceptible Sp(PSSP)isolates.More than 90% of PNSSP were multidrug resistant strains.Conclusion The antimicrobials resistant Sp isolated from children with respiratory tract infection in the area have become a severe problem.

关 键 词：肺炎链球菌 抗生素 耐药性 微生物 微生物敏感性试验 儿童 

分 类 号：R446.5[医药卫生—诊断学]