290例生殖泌尿系统支原体、衣原体感染耐药性分析  

Mycoplasma and Chlamydia Rptoductive Tract:Rwsistance Analysis and Countermeasures in 290 Case

作　　者：孙春梅[1] 吕本云[1] 高茜[1] 于红燕[1] 徐景环[2] 王红英[2] 贺树凤[2] 

机构地区：[1]滨州市立医院,山东滨州256617 [2]滨州市人民医院,山东滨州256610

出　　处：《中国医疗前沿》2007年第23期22-24,共3页China Healthcare Innovation

摘　　要：目的观察290例生殖泌尿道支原体、衣原体感染情况,分析其对抗菌药物的耐药性并提出治疗对策。方法采用单克隆抗体金法检测表原体抗原,采用培养法检测支原体及其药物敏感试验。结果290例标本检出沙眼衣原体(Ct)阳性21例,阳性率为7.24%;检出支原体阳性119例,阳性率为41.03%,其中解脲脲支原体(Uu)阳性率为28.62%(83例),人支原体(Mh)阳性率为3.10%(9例),Uu+Mh混合感染阳性率为6.55%(19例),Uu+Ct混合感染阳性率为3.10%(9例),支原体药敏试验结果显示,Uu对红霉素、罗红霉素耐药率分别为64.83%、62.63%,Mh也成同样趋势,两种支原体合并感染的耐药率升高;强力霉素、米诺环素、交沙霉素有较高的抑菌能力。结论随着支原体感染病例不断增多,出现多重耐药现象。临床应参照药敏试验结果选3用抗菌药物,并进行足量、足疗程治疗,以减少耐药菌株的产生,强力霉素、米诺环素、交沙霉素可作为临床支原体感染首选药。Objective To observe the situation of Mycoplasma and Chlamydia trachomatis (Ct)Infection in the patients with reproductive tract infection (RTI),and their antibiotic resistance analysis and therapeutic strategies.Methods To analyze Ct antibody with monoclonal antibody immunogold filtration assay,and to detect Mycoplasma and their drug sensitivity with culture method. Results From 290 specimens there were 21 cases who had Ct (7.24%),and 119 cases who had Mycoplasma (41.03%).The single infection of Ureaplasma urdalyticum(Uu) was in 83cases(28.62%) and of Mycoplasma hominis(Mh) in 9 cases(3.10%),respectively, Uu+Mh were in 19cases (6.55%).Uu+Ct were in17 cases (3.10%).The result of drug sensitivity showed that the drug tesisrance of Uu to erythtomycin was 64.83%,to roxithromgcin wsa 62.63%.Mh was also with the similar tendency.The mixed ingections rate was elevated.Doxycycline,minocuyclme,and josamycin had the higher bacteriostatic ability.Congclusions With the growing number of mucoplasma infections,and large-scale application of antibiotics the multidrug-tesistance was occurred,so it is important to clinical reference to the selection of antibiotc susceptibility test results,and sufficient and adequate course oftherapy to reduce the selection of resistant strains.Experimental evidence showed doxycycline,minocycline and josamycin can be wsed as the first choice for clinical medicine in mcoplasma infection.

关 键 词：支原体 沙眼衣原体 解脲脲支原体 人支原体 药敏 耐药性 

分 类 号：R446.5[医药卫生—诊断学]