α-干扰素在新生血管性青光眼手术中的应用  

The effect of Alpha Interferon in neova-scular glaucoma filtration surgery

作　　者：孙建西[1] 王青[1] 马玉芳[1] 云亚歌[1] 

机构地区：[1]青海医学院附属医院眼科

出　　处：《中国眼耳鼻喉科杂志》1998年第2期29-30,36,共3页Chinese Journal of Ophthalmology and Otorhinolaryngology

基　　金：青海省卫生厅青年科学研究基金

摘　　要：目的:为明确α-IF在新生血管性青光眼手术后,对滤过泡瘢痕形成及虹膜新生血管的影响。方法:将46眼新生血管性青光眼随机分为α-IF治疗组25眼和对照组21眼。治疗组术中或术后采用α-IF玻璃体、半球后、结膜下注射,术后随访6～15个月;对照组不用干扰素。结果:α-IF治疗组手术成功率为84%,对照组为23.81%(P<0.01);功能性滤过泡眼数,治疗组为16/25,对照组4/21,P<O.01;虹膜新生血管消失眼数,治疗组为20/25,对照组为3/21,P<0.01;治疗组未见明显的眼部及全身副作用。结论:α-IF能提高新生血管性青光眼手术的成功率,并减少虹膜新生血管。To determine the cicatrization and iris neovascularization effect of Alpha-Interferon(a-IF)after filtration surgery of neovascular glaucoma. Methods. We randomly divided 38 cases (46eyes) into two groups. 25 eyes were in the study group and received inoperative or postoperative subconjunctiva], sub-Tenon’s and intravitreal injection of α-IF, and 21 eyes were in the control group. Results. The mean follow-up was 8.4 months (range 6 to 15 months).The success rate in the α-IF group was 84% and the control group was 23.81% (P&lt;0.01), A functional filtering bleb was 16/25 eyes in the study group and 4/21 in the control group, (P&lt;0.01). Iris neovacularization regressed in 20 of 25 eyes in the study group and 3 of 21 eyes in the control group (P&lt;0.01) control group 3/21 (P&lt;0.01). There were no significant side effects from the a-IF. Conclusion .The results show that a-IF may raise the success rate of filtration surgery and decrease iris neovascularization.

关 键 词：Α-干扰素 新生血管性青光眼 滤过手术 

分 类 号：R76[医药卫生—耳鼻咽喉科] R77[医药卫生—临床医学]