冷藏人胎胰岛细胞移植治疗胰岛素依赖型糖尿病的初步观察  

Preliminary study on transplatation of cryopreserved human fetal pancreatic islets in IDDM patients

作　　者：潘长玉[1] 陆菊明[1] 田慧[1] 汪洋[1] 李亚里[1] 刘成贵[1] 李晖[1] 黄云中[2] 张中兴[2] 徐元基[2] 任会明[2] 任泗逮 

机构地区：[1]解放军总医院 [2]军事医学科学院

出　　处：《军医进修学院学报》1991年第1期32-36,共5页Academic Journal of Pla Postgraduate Medical School

摘　　要：本文采用冷冻保存人胎胰岛细胞对11例IDDM患者(男7,女4;年龄22～41岁,病程2～10年)进行移植。随机分腹腔移植5例;三角肌移植6例。平均移植胎胰数为10.45±0.93个(10～13个)。移植过程未用免疫抑制剂。于移植前和移植后1、2、6个月,分别对临床症状、血糖、HbA_1、24小时尿糖、C肽、肌酐清除率(Ccr)、OK_(T4)、OK_(T8)以及每日胰岛素需要量等进行了评价。结果显示移植后代谢指标无改善,胰岛素需要量未明显减少。未达予期效果。因此认为冷冻保存人胎胰岛细胞在体外活性与临床疗效之间存在矛盾,其原因有待进一步阐明。The transplantation of cryopreserved human fetal pancreatic islet in the form of 10—13 fetal pancreases was performed in 11 IDDM patients(7 males, 4 females, aged 22—41 years with history of 2—10years), intraperitoneally in 5 and intramuscularly in 6 with 10—13 fetal pancreases. No immunosuppressive agent was used. Before the transplantation and 1, 2, 6 months after implantation, the clinical symtoms, blood glucose, HbAl, 24-hour urine glucose, OKT4, OKT8 and daily insulin requirment were evaluated respectively. The resuls showed that after transplantation there was no metabolic eltectand the daily insulin requirment was not signicantl reduced. Thus, the discrepancy between the viability of deep-frozen human pancreatic islet in vitro and that in IDDM patient remains to be elucidated further.

关 键 词：糖尿病 胰岛素依赖型 胰岛移植 组织保存冷冻 

分 类 号：R587.1[医药卫生—内分泌]