无水三氯化铁催化合成对叔丁基苯甲酸甲酯  

Synthesis of 4-tert-butyl-benzoic acid methyl ester catalyzed by anhydrous iron trichloride

作　　者：胡为民[1] 赵红英[2] 郭彦辉[2] 马晨红[1] 

机构地区：[1]河南省科学院同位素研究所,河南郑州450052 [2]郑州大学,河南郑州450052

出　　处：《河南科学》2002年第5期508-510,共3页Henan Science

摘　　要：以对叔丁基苯甲酸和甲醇为原料 ,无水三氯化铁作催化剂 ,采用蒸馏分水工艺 ,回流温度下合成对叔丁基苯甲酸甲酯。讨论了催化剂用量、反应时间、醇酸摩尔比等因素对反应转化率的影响。最佳反应条件为 :n(甲醇 )∶n(对叔丁基苯甲酸 ) =5∶1,催化剂用量 8.4 % (相对于对叔丁基苯甲酸 ) ,反应时间为 3小时 ,反应温度为回流温度 ,产品转化率为 92 .5 %。经沸点测定。The synthesis of 4 tert butyl benzoic acid methyl ester was performed by methanol and 4 tert butyl benzoic acid using anhydrous iron trichoride as catalyst under fractionating distillation. Factors influencing the reaction were discussed. The best reaction conditions as follow: molar ratio of methanol to 4 tert butyl benzoic acid=5∶1, mass ratio of catalyst to 4 tert butyl benzoic acid 8.4%, reaction time 3 hour, Yield of the product was 92.5%. The results of b.p. determination and index of refraction indicated thah the product was 4 tert butyl benzoic acid methyl ester.

关 键 词：催化合成 无水三氯化铁 对叔丁基苯甲酸甲酯 催化剂 酯化反应 反应条件 

分 类 号：TQ245.24[化学工程—有机化工]