环丙烷骨架赤霉素衍生物的合成及结构鉴定  

Synthesis and Structural Determination of GA Derivative with Cyclo Propyl Skeleton

作　　者：刘建平[1] 

机构地区：[1]云南大学药学院,昆明650091

出　　处：《云南民族学院学报（自然科学版）》2002年第4期222-224,共3页Journal of Yunnan University of The Nationalities(Natural Sciences Edition)

基　　金：云南省自然科学基金资助项目 (2 0 0 0B0 0 0 1R)

摘　　要：报道含有 9,15 -环丙烷结构的赤霉素衍生物 (3)的合成 .作者所报道的形成 9,15 -环丙烷结构赤霉素衍生物的方法与原类似方法比较 ,条件温和 ,易于操作 .所得新化合物 (3)的结构除由核磁共振 (1HNMR ,13 CNMR) ,质谱 (MS)及高分辨质谱 (HRMS)证实外 ;还经单晶XHydroxy-9,15-cyclogibberellin derivative (3) was synthesized and its structure was determined by NMR, MS and HRMS. The overall structure and stereochemistry of which was confirmed by its single crystal X-ray crystallography. A mild and easy way to form 9,15-cyclo GA derivative from corresponding ketone was reported.

关 键 词：赤霉素类衍生物 合成方法 结构鉴定 9 15-环丙烷结构 药物合成 反应介质 

分 类 号：R978.1[医药卫生—药品] R914.5[医药卫生—药学]