山茱萸总甙滴眼液局部应用的兔眼通透性研究  被引量：3

Studies on pharmacokinetics of cornus officinalis glycosides eyedrops in rabbit eyes permeability</em> <p class='article-op'> <span id="bdshare" class="bdshare_t bds_tools get-codes-bdshare baidufx"><span><span class="bds_more" style="display: block; width: 62px; height: 29px; background: url(/images/share.gif) no-repeat!important; padding: 0;"></span></span></span> </p> <p class="article-source"> <a href ='/article/read.aspx?id=6902486' class='btnTitle btnIsView' target='_blank'><img alt='在线阅读' src='/images/btn-read.png'/></a><a class='btnTitle btnIsView' href="javascript:showdown('HX605lITuHjiqhRBDLWni+LWeNUOJi2boUtxxVBEbCQ=')"><img alt="下载全文" src="/images/btn-down.png" /></a> <input id="hiddowninfo" type="hidden" value="HX605lITuHjiqhRBDLWni+LWeNUOJi2boUtxxVBEbCQ="/> </p> <div class="collect" style="display: none"> <h5>我的收藏</h5> <div class="cnt"> <p> 名 称：<input type="text" name="collTitle" id="collSumTitle" /> </p> <p> 注 释：<input type="text" name="collRemark" id="collSumRemark" /> 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href='/writer/article.aspx?id=100000009673120' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%b5%b5%e6%9d%be%e6%bb%a8%5d' title='赵松滨[1]'>赵松滨[1]</a> <a href='/writer/article.aspx?id=100000030138437' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e6%9e%97%e7%99%bd%e9%9c%9c%5d' title='林白霜[2]'>林白霜[2]</a> <a href='/writer/article.aspx?id=100000000680597' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%b5%b5%e4%b8%96%e8%90%8d%5d' title='赵世萍[3]'>赵世萍[3]</a> <a href='/writer/article.aspx?id=100000001763747' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e4%bb%98%e6%a1%82%e9%a6%99%5d' title='付桂香[3]'>付桂香[3]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=1204&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e6%9a%a8%e5%8d%97%e5%a4%a7%e5%ad%a6%e9%99%84%e5%b1%9e%e5%8d%8e%e4%be%a8%e5%8c%bb%e9%99%a2%e7%9c%bc%e7%a7%91' title='[1]暨南大学附属华侨医院眼科'>[1]暨南大学附属华侨医院眼科</a> <a href='/organ/article.aspx?id=1204&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e6%9a%a8%e5%8d%97%e5%a4%a7%e5%ad%a6%e9%99%84%e5%b1%9e%e5%8d%8e%e4%be%a8%e5%8c%bb%e9%99%a2%e7%97%85%e7%90%86%e7%94%9f%e7%90%86%e6%95%99%e7%a0%94%e5%ae%a4' title='[2]暨南大学附属华侨医院病理生理教研室'>[2]暨南大学附属华侨医院病理生理教研室</a> <a href='/organ/article.aspx?id=3222&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e4%b8%ad%e6%97%a5%e5%8f%8b%e5%a5%bd%e5%8c%bb%e9%99%a2%e4%b8%b4%e5%ba%8a%e5%8c%bb%e5%ad%a6%e7%a0%94%e7%a9%b6%e6%89%80%e8%8d%af%e7%89%a9%e8%8d%af%e7%90%86%e5%ae%a4' title='[3]中日友好医院临床医学研究所药物药理室'>[3]中日友好医院临床医学研究所药物药理室</a> <em> </em></p><p class='from'><strong>出　　处：</strong><a href='/journal/summary.aspx?gch=92134X' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e7%9c%bc%e7%a7%91%e6%96%b0%e8%bf%9b%e5%b1%95%5d' title='眼科新进展'>《眼科新进展》</a>2002年第5期312-314,共3页<em>Recent Advances in Ophthalmology</em></p><p class='fund'><strong>基　　金：</strong>广东省中医药局科研课题(编号:302004);广东省医学科研基金课题(编号:A20023227)</p><p class='abstrack'><strong>摘　　要：</strong>　目的　本研究首次研制出山茱萸总甙 (cornus officinalis glycosides,COG)滴眼液 ,并用高效液相色谱法 (high performance liquid chromatography,HPLC)对不同剂量该滴眼液在兔眼房水经时过程的异同进行研究。方法　将 3种不同剂量 COG滴眼液 50 μL分别滴入 3组兔眼下睑结膜囊内 ,在 4h内定时采取房水作为测试样本 ,经处理后 ,用高效液相色谱仪测定样本中的没食子酸的质量浓度。结果　 COG滴眼液滴眼后 ,能被吸收进入房水。给药后 1 h时 ,3组房水药物浓度均为最高值。统计分析显示 :A组 (5g· L-1COG)与 B(1 0 g· L-1COG)、C(2 0 g·L-1COG)组之间有显著差异性 (P<0 .0 5)。结论　COG滴眼液滴眼能被吸收进入房水 ,在给药 1 h时 。<em><Abstrcat>ObjectiveTo observe the timecourse in aqueous humor of rabbits tested with the cornus officinalis glycosides (COG) eyedrops in the eyes by high performance liquid chromatography(HPLC). MethodsAqueous humor levels of gallic acid following 50μL three different dosages of COG eyedrops were determined intervals for 4h by HPLC.ResultsThe highest concentration of the COG eyedrops was in 1h after dropped. There were significant difference between group A and B, groupA and C(P<0.05). Conclusion COG eyedrops can be absorbed into aqueous humor. The peak concentration of the COG eyedrops is in 1h after dropped.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/subject/article.aspx?id=1834770' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%b1%b1%e8%8c%b1%e8%90%b8%e6%80%bb%e7%94%99%5d' title='山茱萸总甙'>山茱萸总甙</a> <a href='/subject/article.aspx?id=6645004' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e6%88%bf%e6%b0%b4%5d' title='房水'>房水</a> <a href='/subject/article.aspx?id=5973031' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e9%ab%98%e6%95%88%e6%b6%b2%e7%9b%b8%e8%89%b2%e8%b0%b1%e4%bb%aa%5d' title='高效液相色谱仪'>高效液相色谱仪</a> <a href='/subject/article.aspx?id=864696' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e8%8d%af%e4%bb%a3%e5%8a%a8%e5%8a%9b%e5%ad%a6%5d' title='药代动力学'>药代动力学</a> <a href='/zk/search.aspx?key=K%3d%5b%e5%85%94%5d' title='兔'>兔</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR988.1' title='R988.1'>R988.1</a>[<a href = '/domain/article.aspx?id=515' >医药卫生—药品</a>] </p> </div> <div id="content_wzxg" name="wzxg" class="article-graph"> <object width="695" height="250" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" id="FlashID"> <param value="../flash/relation.swf" name="movie"> <param value="high" name="quality"> <param value="opaque" name="wmode"> <param value="6.0.65.0" name="swfversion"> <param value="dataUrl=/ajax/articlerelativegraph.ashx?id=6902486" name="flashVars"> <embed width="695" height="250" src="../flash/relation.swf" type="application/x-shockwave-flash" quality="high" wmode="opaque" flashvars="dataUrl=/ajax/articlerelativegraph.ashx?id=6902486"> </embed> </object> </div> <div class="article-relate-list"> <div class="relate-list"> <p id="ckwx_br"> </p> <h2 name="ckwx" id="ckwx">参考文献：</h2> <div id="listckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jckwx_br"> </p> <h2 name="2jckwx" id="2jckwx">二级参考文献：</h2> <div id="list2jckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="ohwx_br"> </p> <h2 name="ohwx" id="ohwx">耦合文献：</h2> <div id="listohwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="yzwx_br"> </p> <h2 name="yzwx" id="yzwx">引证文献：</h2> <div id="listyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jyzwx_br"> </p> <h2 name="2jyzwx" id="2jyzwx">二级引证文献：</h2> <div id="list2jyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="tbywx_br"> </p> <h2 name="tbywx" id="tbywx">同被引文献：</h2> <div id="listtbywx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="xgqklw_br"> </p> <h2 name="xgqklw" id="xgqklw">相关期刊文献：</h2> <div id="listxgqklw"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> </div> </div> <div class="article-about"> <div class="about-box"> <h5 class="name">相关的主题<tt><a class="hide" href="#"></a></tt></h5> <div class="about-list"> </div> </div> <div class="about-box"> <h5 class="name">相关的作者对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> <div class="about-box"> <h5 class="name">相关的机构对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> </div> </div> </div> <script type="text/javascript" src="/scripts/articlerelation.min.js"></script> <script type="text/javascript" src="/scripts/articlerightrelation.min.js"></script> <script type="text/javascript" src="/scripts/articledown.min.js"></script> <div class="layer-box download" id="downloadlayer" style="display: none"> <div class="close"> <a onclick="closedown()" href="javascript:void(0)"> <img src="/images/layer-close.png" width="21" height="21" alt="" /> </a> </div> <h5 class="layer-title">下载全文</h5> <div id="downloadinfo"></div> </div> <div class="layer-box download" id="downloadlayer2" style="display:none;min-height:100px;width:500px;"> <p> <img src="/images/loading2.gif" width="64" height="64"> <span style="font-size:20px;vertical-align:middle;padding-bottom:50px;">正在链接到云南高校图书馆文献保障联盟下载...</span> </p> </div> <script id="bdshare_js" data="type=tools&uid=0" type="text/javascript"></script> <script type="text/javascript"> $(function () { var rd = GetQueryString("rd"); 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