54例妊娠期肝内胆汁淤积症临床分析  

Clinical analysis of 54 cases of intrabepatic cholestasis of pregnancy

作　　者：沈海滨[1] 乔福元[2] 张华[1] 

机构地区：[1]湖北省武汉市普爱医院妇产科,430033 [2]华中科技大学同济医学院附属同济医院妇产科

出　　处：《中国妇幼保健》2004年第4X期62-63,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨妊娠期肝内胆汁淤积症(ICP)孕妇肝功能指标改变,围产儿结局。方法:对该院2001年1月~2003年12月间54例妊娠期肝内胆汁淤积症患者临床资料进行回顾性分析。结果:ICP孕妇血清转氨酶(ALT、AST)及胆汁酸(TBA)水平升高,较正常对照组有显著性差异;ICP早产、新生儿窒息率明显升高。结论:ICP孕产妇预后良好,围产儿危险增加,必须高度重视,加强胎儿监护及药物治疗,适时剖宫产终止妊娠将明显改善围产儿预后。Objective: To evaluate changes of maternal liver function and analyze fetal prognosis in intrahepatic cholestasis of pregnancy (TCP). Methods: 54 patients with ICP were studied retrospectively. Results: Patients with intrahepatic cholestasis of pregnancy showed a significant elevation of total bile acid and transaminases in serum when compared with the control group (P< 0.05). Incidences of preterm delivery and neonatal asphyxia significantly increased in cases with ICP. Conclusion: ICP affects mothers little but poses great risk to the fetuses. The execution of cesarean section at proper time can improve the prognosis of fetuses.

关 键 词：妊娠期肝内胆汁淤积症 肝功能 胎儿 

分 类 号：R714.25[医药卫生—妇产科学]