Effect of β-blocker atenolol on spatial dispersion of ventricular repolarization of sheep following acute myocardial ischemia  

β阻滞剂阿替洛尔对绵羊急性心肌缺血后心室复极化离散度的影响(英文)

作　　者：WANG Le-Xin (School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia) 

出　　处：《Acta Pharmacologica Sinica》2002年第7期49-52,共4页中国药理学报（英文版）

摘　　要：AIM: To investigate the effect of β-blockers on spatial dispersion of ventricular repolarization following acute myocardial ischemia. METHODS: Twenty sheep were randomized into control (normal saline, iv) and atenolol (1.5 mg/kg, iv) group. Acute myocardial ischemia was induced by occlusion of the obtuse marginal coronary artery. Unipolar ECG was simultaneously acquired from 64 epicardial sites in both ischemic and non-ischemic regions. Activation-recovery intervals (ARI), an index of ventricular repolarization, was determined from the epicardial ECG. The difference between the longest and shortest ARI was defined as ARI dispersion. RE-SULTS: Ischemic zone in atenolol group was less than that of control group (13 % ± 2 % vs 19 % ± 3 % , P - 0.04). In the control group, pooled ARI dispersion was increased by (18 ± 21), (27 ± 21), and (16 ± 10) ms at 30, 60, and 90 min of coronary artery occlusion respectively (P 【 0.01), whereas in the atenolol group, ARI dispersion was only increased by (6 ± 4), (6 ± 7), and (2±7) ms respectively (P】0.05). CON-CLUSION: These findings indicate that atenolol suppresses ischemia-induced increase in spatial dispersion of ventricular repolarization, which may explain the antiarrhythmic effect of (β-blockers.AIM: To investigate the effect of β-blockers on spatial dispersion of ventricular repolarization following acute myocardial ischemia. METHODS: Twenty sheep were randomized into control (normal saline, iv) and atenolol (1.5 mg/kg, iv) group. Acute myocardial ischemia was induced by occlusion of the obtuse marginal coronary artery. Unipolar ECG was simultaneously acquired from 64 epicardial sites in both ischemic and non-ischemic regions. Activation-recovery intervals (ARI), an index of ventricular repolarization, was determined from the epicardial ECG. The difference between the longest and shortest ARI was defined as ARI dispersion. RE-SULTS: Ischemic zone in atenolol group was less than that of control group (13 % ± 2 % vs 19 % ± 3 % , P - 0.04). In the control group, pooled ARI dispersion was increased by (18 ± 21), (27 ± 21), and (16 ± 10) ms at 30, 60, and 90 min of coronary artery occlusion respectively (P < 0.01), whereas in the atenolol group, ARI dispersion was only increased by (6 ± 4),

关 键 词：heart ventricle ELECTROCARDIOGRAPHY myocardial ischemia SHEEP ATENOLOL 

分 类 号：R96[医药卫生—药理学]