Effects of diacetyl guan-fu base A on pacemaker cells in sinoatrial bnode of rabbits  

关附乙酯对兔窦房结起搏细胞的作用(英文)

作　　者：孙华[1] 张庆柱[2] 王如斌[3] 纪建波 

机构地区：[1]山东大学药学院药理学教研室 [2]山东大学药学院有机化学教研室 [3]山东大学药学院药理学教研室 济南 [4]中国 250012

出　　处：《Acta Pharmacologica Sinica》2002年第7期53-56,共4页中国药理学报（英文版）

基　　金：Project suported by he Science and Technology Committee of Shandong Province,№ 4138842.

摘　　要：AIM: To study the electrophysiological effects of diacetyl guan-fu base A (DGFA) on pacemaker cells in sinoatrial (SA) node. METHODS: Intracellular micro-electrode method was used to record parameters of action potential (AP) in SA node of rabbits. RESULTS: DGFA could not only slow down spontaneous firing frequency (SFF), mean rate of repolarization (MRR), and rate of diastolic depolarization (RDD), but also prolong diastolic interval (DI) and duration of action potential (APD) in a concentration-dependent manner in SA node. Furthermore, DGFA markedly decreased the maximum rate of depolarization (MRD) with a slight reduce of the amplitude of action potential (APA) and there was no significant effect on the maximal diastolic potential (MDP). The decrease in SFF caused by DGFA was not affected by atropine (0.05 mg/L). CONCLUSION: The effects might be due to the reduction of calcium influx and potassium efflux, and the muscarinic receptors were not involved.目的:研究关附乙酯(DGFA)对窦房结起搏细胞电生理学的影响.方法:采用细胞内微电极技术记录家兔窦房结动作电位(AP)参数.结果:DGFA不仅能够减慢自主性激发频率(SFF),平均复极化速率(MRR),舒张期除极化速率(RDD),而且以剂量依赖性方式延长窦房结舒张期间隔(DI)和动作电位时程(APD).此外,DGFA显著降低除极化最大速率(MRD),并伴有动作电位幅度(APA)的轻微下降,对最大舒张电位(MDP)无显著作用.DGFA降低自主性激发频率的作用不受阿托品(0.05 mg/L)的影响.结论:DGFA这些作用可能是通过减少钙离于内流及钾离子外流产生的,而非阻断M受体.

关 键 词：diacetyl guan-fu base A sinoatrial node ELECTROPHYSIOLOGY action potentials 

分 类 号：R9[医药卫生—药学]