雌激素调节能量代谢的神经元保护作用  

The Neuroprotective Effect of Estrogen is Associated with Regulation Energy Metabolism

作　　者：沈丽霞[1] 张丹参[1] 

机构地区：[1]河北北方学院药学系

出　　处：《神经药理学报》2012年第1期28-33,共6页Acta Neuropharmacologica

基　　金：河北省自然科学基金项目(No.C2011405014;C2009001026);河北省科技攻关计划项目(No.07276166);河北省教育厅项目(No.2010212)

摘　　要：大量研究表明雌激素水平降低与阿尔茨海默病的发生和发展有密切关系。雌激素具有神经保护作用,但其机制尚不明确。本文主要从能量代谢角度,综述了雌激素通过改善葡萄糖代谢、调节大脑代谢及提高线粒体功能,有效保护神经细胞的作用。为应用雌激素或雌激素替代物维护神经系统的功能和防治阿尔茨海默病提供一定的理论依据。Estrogen has been demonstrated to be involved in the development and progress of Alzheimer’s disease. Numerous studies show the neuroprotective effects of estrogen, but the underlying mechanism remains unclear. Here,we discussed the neuroprotective effects of estrogen,particularly focusing on the energy metabolism related to improvement of glucose metabolism,regulation of the brain metabolism and enhancement of mitochondrial function. Application of estrogen or estrogen substitutes to maintain the nervous system function and to prevent and control Alzheimer’s disease could be a fruitful field in future studies.

关 键 词：雌激素 阿尔茨海默病 线粒体 能量代谢 

分 类 号：R964[医药卫生—药理学]