EDRF-like Actions of Homoarginine Oligopeptide  

作　　者：顾鸣镝 彭师奇 蒋秀荣 郭雪清 蔡孟深 张力 董淑云 张连元 唐朝枢 

机构地区：[1]National Laboratory of Natural and Biomimetic Drugs,Beijing Medical University.Beijing 100083,PRC [2]Laboratory of Cardiopulmonary Endocrinology,Beijing Medical University,Beijing 100083,PRC

出　　处：《Progress in Natural Science:Materials International》1993年第2期155-159,共5页自然科学进展·国际材料（英文版）

基　　金：Project supported by the Natural Science Foundation of Beijing,China.

摘　　要：Based on the advances in the research of endothelium derived relaxing factor,thehomoarginine oligopeptide was designed and synthesized.Its vasodilation and depressor actions on Wistarrats were observed,and the effects have been found to be independent of the vascular endothelium.Thestrong EDRF-like action of the oligopeptide provides an excellent lead compound in the structure-activityrelationship(SAR)researches of homoarginine and derivatives.Based on the advances in the research of endothelium derived relaxing factor,the homoarginine oligopeptide was designed and synthesized.Its vasodilation and depressor actions on Wistar rats were observed,and the effects have been found to be independent of the vascular endothelium.The strong EDRF-like action of the oligopeptide provides an excellent lead compound in the structure-activity relationship(SAR)researches of homoarginine and derivatives.

关 键 词：HOMOARGININE ohgopeptide SYNTHESIS EDRF-like effect 

分 类 号：N[自然科学总论]