Preventive effects of Xin-Kang oral liquid on viral myocarditis in mice  

作　　者：ZHAO Hong WAN Sujun 

机构地区：[1]Cardiovascular Institute and Fu Wai Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100037,China [2]Guang An Men Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100053,China

出　　处：《Progress in Natural Science:Materials International》2002年第2期27-29,83,共4页自然科学进展·国际材料（英文版）

基　　金：Supported by the National Natural Science Foundation of China (Grant No. 39770916)

摘　　要：To investigate the preventive effects of Xin-Kang oral liquid on myocarditis induced by Coxsakie virus B (CVB), the medicine was given to mice two days prior to the challenge of mice with the CVB to induce myocarditis. The oral liquid was continuously given to mice for 20 days and quantitative histological changes at various stages of the myocarditis were observed. The pathological changes on the cardiac surface were significantly reduced in Xin-Kang treated mice compared to those in control group (P【0.01), and the occurrence of severe myocardium damage (massive cardiac tissue death and degradation) was less in the Xin-Kang group than the groups either challenged with CVB or treated 'with interferon. The group treated with 0. 015g per gram body weight per day showed significant improvement over the viral group (P【0. 01) . The results proved that Xin-Kang could protect the cardiac muscle from viral infection and accelerate recovery of damaged cardiac tissue.To investigate the preventive effects of Xin-Kang oral liquid on myocarditis induced by Coxsakie virus B (CVB), the medicine was given to mice two days prior to the challenge of mice with the CVB to induce myocarditis. The oral liquid was continuously given to mice for 20 days and quantitative histological changes at various stages of the myocarditis were observed. The pathological changes on the cardiac surface were significantly reduced in Xin-Kang treated mice compared to those in control group (P<0.01), and the occurrence of severe myocardium damage (massive cardiac tissue death and degradation) was less in the Xin-Kang group than the groups either challenged with CVB or treated 'with interferon. The group treated with 0. 015g per gram body weight per day showed significant improvement over the viral group (P<0. 01) . The results proved that Xin-Kang could protect the cardiac muscle from viral infection and accelerate recovery of damaged cardiac tissue.

关 键 词：VIRAL MYOCARDITIS Xin-Kang oral liquid histomorphology. 

分 类 号：R541[医药卫生—心血管疾病]