枸杞多糖对四氧嘧啶损伤的离体大鼠胰岛细胞的保护作用  

The Protective Effects of Lychan barbarian Polysaccharide on Alloxan-induced Isolated Islet Cells Damage in Rats

作　　者：徐曼艳[1] 张红锋[1] 王煜飞[2] 

机构地区：[1]华东师范大学生命科学学院,上海200062 [2]上海第一人民医院糖尿病研究室,上海200085

出　　处：《中药材》2002年第9期649-651,共3页Journal of Chinese Medicinal Materials

摘　　要：目的:观察枸杞多糖(LBP)对四氧嘧啶(alloxan)诱导的胰岛细胞损害的保护作用。方法:应用体外培养的大鼠胰岛细胞,分别检测alloxan、LBP及其联合对胰岛细胞超氧化物歧化酶(SOD)活性和丙二醛(MDA)生成的影响。结果:LBP明显增强受损胰岛细胞内SOD的活性,提高了胰岛细胞的抗氧化能力,减轻了过氧化物对细胞的损伤,降低MDA的生成量。结论:LBP对alloxan损伤的离体大鼠胰岛细胞有一定的保护作用。Objective: To study the effects of Lycium barbarum polysaccharide (LBP) on alloxan-induced isolated islet cells damage in rats. Methods: Isolated islet cells from SD rat were cultured in vitro. SOD activity and MDA content in rat islet cells incubated with alloxan or alloxan combined LBP were measured. Results: Alloxan induced a significant decrease in SOD activity and a increase in MDA production, which were inhibited by LBP. Conclusion: LBP had protective effects on alloxan-induced isolated rat islet ceus damage.

关 键 词：枸杞多糖 四氧嘧啶 离体大鼠 胰岛细胞损伤 胰岛细胞 保护作用 

分 类 号：R285.5[医药卫生—中药学]