丹参及光量子化丹参对脑缺血模型脑ATP和血栓素B_2/前列腺素F_(1α)的影响  

Effects of Radix Salviae Miltiorrhize and Radix Salviae Miltiorrhizae with Ultraviolet Liquid Irradiation on Brain ATP and TXB_2/PGF_(1α) in Cerebral lschemia-Reperfusion Model

作　　者：阎福岭[1] 王建平[1] 袁真丽[1] 方树友[1] 许予明[1] 卢宏[1] 韩雄[1] 

机构地区：[1]河南医科大学第一附属医院神经内科,郑州450052

出　　处：《中国中西医结合杂志》1997年第S1期56-57,281,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：制作兔不完全性脑缺血再灌注模型,检测脑组织 ATP、血栓素 B_2(TB_2)和前列腺素 F_(1α)(PGF_(1α))含量变化及丹参、光量子化丹参对上述指标的影响。结果表明:脑缺血再灌注模型脑组织 ATP 含量降低,TXB_2/PGF_(1α)。比值升高,而丹参及光量子化丹参可明显回升ATP 含量,降低 TXB_2/PGF_(1α)。比值。丹参具有活血化瘀之功效,可能是通过降低 TXB_2/PGF_(1α)比值,恢复供血,提高 ATP 含量而起作用,光量子化可明显增强丹参的作用,可视为丹参的一种新炮制方法,更有利于丹参的作用发挥。The models of incomplete cerebral ischemia and reperfusion in rabbits were established.Contents of the ATP,TXB₂ and PGF₁ in brain tissue of the models were examined.Effects of Radix Salviae Miltiorrhize（RSM）and RSM with ultraviolet liquid irradiation（ULl）on these indexes were observed.ATP was reduced and the ratio of TXB₂/PGF₁α increased in ischemic models. Nevertheless RSM and RSM with ULI could reduce the ratio of TXB₂/PGF₁α and increase the content of ATP.RSM might im- prove the cerebral circulation by reducing ratio of tXB₂/PGF₁α and then increase the level of ATP in brain tissue.The function of RSM could be enhanced by ULI.

关 键 词：丹参 光量子液疗 脑缺血再灌注 

分 类 号：R2-031[医药卫生—中西医结合]