黄角汤对脑梗塞急性期大鼠血液流变学指标等的影响  

Experimental Study of Huangjiao Mixture on Hemorheology of Acute Cerebral Infarction in Rats

作　　者：常学辉[1] 张介眉[2] 陈国华[2] 

机构地区：[1]湖北中医学院,博士生武汉430061 [2]湖北武汉市第一医院,武汉430022

出　　处：《中国中医急症》2002年第5期379-380,共2页Journal of Emergency in Traditional Chinese Medicine

摘　　要：目的通过观察黄角汤对脑梗塞急性期大鼠血液流变学指标等的影响以探讨其治疗脑梗塞急性期的作用机制。方法对大脑中动脉栓塞模型大鼠,选用黄角汤及尼莫地平对脑梗塞急性期大鼠进行治疗,并设正常组及模型组对照。观察各组大鼠血液流变学指标、血浆血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)、一氧化氮(NO)等水平变化。结果模型组大鼠全血粘度高、中、低切值及血浆TXB2值显著高于正常组,6-keto-PGF1α、NO值显著低于正常组(P均<0.01)。黄角汤组全血粘度高、中、低切值及TXB2、6-keto-PGF1α、NO值有不同程度的恢复(P<0.01或0.05)。结论黄角汤治疗脑梗塞急性期的机制与其降低血粘度、提高NO水平、纠正血液中TXA2-PGI2平衡失调的作用有关。Objeive:To investigate the possible mechani sm of Huangjiao Mixture(HJT)on acute cerebral infarction(ACI )by observing the effect of JIT on Hemo rheology,TXB 2 ,6-keto -PGF1 1α and NO.Methods :Rats of right middle cerebral artery ischenia were devided into four grou ps randomly:normal controlled grou p,model group,HJT group and nimodipine grou p.The change of hemorheology,TXB 2 ,6-keto -PGF1 1α and NO in plasma were observed.Results:Compared with normal controlled group,the levels of high,middle,low viscosity of plasma and TXB 2 of model group increased significatly.The level of NO,6-keto -PGIF1 1α decreased significaltly.Both the levels of hi gh,midle,low viscosity in plasma,T XB 2 ,6-keto -PGF1 1α and NO of HJT group were recovered.Conclusion:The mechanism of HJT on ACI is connected with decrea sing hemorheology,increasing the l evel of NO,recovering the balance of TXA 2 /PGI 2 .

关 键 词：黄角汤 脑梗塞 急性期 血液流变学 一氧化氮 TXB2 6-KETO-PGF1Α 动物模型 

分 类 号：R277.7[医药卫生—中医学] R285.5