绝经妇女雌激素补充疗法治疗骨质疏松症的研究  

A Study on the Effect of Estrogen Replacement Therapy in Postmenopausal Osteoporosis

作　　者：彭幼玲[1] 陈党生[1] 吴文[1] 

机构地区：[1]广东省人民医院,广东广州510080

出　　处：《实用妇产科杂志》2002年第5期299-300,共2页Journal of Practical Obstetrics and Gynecology

摘　　要：目的 :探讨绝经后妇女骨质疏松的治疗方法。方法 :将 86例绝经后骨质疏松患者随机分成 A组 (实验组 ,口服利维爱加钙尔奇 - D片 )、B组 (对照组 ,单服钙尔奇 - D片 ) ,比较两组的更年期症状与骨密度 (BMD)、血清降钙素 (h-CT)、血清骨钙素 (BGP)和甲状旁腺素 (PTH)等指标的变化情况。结果 :A组的临床有效率为 79.0 7% ,明显高于对照组(5 8.14 % ,P<0 .0 5 )。A组 BMD明显增加 (P<0 .0 5 ) ,BGP、h- CT水平显著增高 (P<0 .0 1) ,PTH水平显著降低 (P<0 .0 5 )结论 :口服利维爱加钙尔奇 - D片 。Objectives:To view the curative effect of estrogen replacement therapy(ERT) in postmenopausal osteoporosis.Methods: 86 cases of postmenopausal osteoporosis were divided into experimental group(given oral Livial and Caltrated D)and control group(given oral Caltrated D).The clinically effective rates and bone metabolite indexes including bone mass density(BMD),bone glaconfaining protein(BGP),calcitonin(CT)and parathormone(PTH)were measured.Results: The clinically effective rate in experimental group was 79.07%,its significantly higher than that in control group(58.14%, P < 0.05 ).The levels of BMD,BGP,CT were increased significantly( P <0.05, P <0.01),and PTH was decreased significantly( P <0.05)in erperimental group than that in control group. Conclusions: It was suggested that ERT was one of an effectively therapeutic method for postmenopausal osteoporosis.

关 键 词：绝经 雌激素补充疗法 骨质疏松症 骨密度 骨代谢 

分 类 号：R681[医药卫生—骨科学] R711.75[医药卫生—外科学]