环孢素A对肾移植患者肝功能的影响  

The Effect of Cyclosporin a on Liver Function of Renal Transplantation Patients

作　　者：杨万兴[1] 封永勇[2] 

机构地区：[1]第三军医大学野战外科研究所大坪医院药剂科,重庆400042 [2]贵阳中医学院97级,实习生贵州贵阳510000

出　　处：《中国药业》2002年第10期41-42,共2页China Pharmaceuticals

摘　　要：目的:阐明长期应用环孢素A(CsA)对肾移植患者肝功能的影响。方法:查阅国内外文献,综述CsA致肾移植患者肝功能损害的机理及临床表现。结果:CsA引起肝损害的机理及损害程度皆与血药浓度有关,其临床表现主要为低蛋白、高胆红素血症等。结论CsA在肾移植患者治疗中效果显著,但其对肝损害的影响也应引起重视。Objective:To interpret the effect of long -term application of Cyclosporin A (CsA)on liver function of renal transplantation patients.Methods:By consulting literatures,summarize the mechanism and clinical syndro me of hepatic injury caused by CsA in renal transplantation patients.Results:The mechanism and extent of hepatic i njury caused by CsA all relate to plasma con centration of the drug.The clinical syndromes are mainly hypoproteinmi a and hyperbilirubinemia,etc.Conclusion:CsA has significant effects in the tr eatment for renal transplantation p atients.But one should think highly of its effects on hepatic injury.

关 键 词：环孢素A 肾移植 肝功能 免疫抑制剂 影响 

分 类 号：R979.5[医药卫生—药品] R699.2[医药卫生—药学]