鸡血藤的化学成分研究  

STUDIES ON THE CHEMICAL CONSTITUENTS OF SPATHOLOBUS SUBERECTUS DUNN

作　　者：崔艳君[1] 刘屏[2] 陈若芸[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所,北京100050 [2]中国人民解放军总医院,北京100853

出　　处：《药学学报》2002年第10期784-787,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目 (3 0 0 70 890 ) .

摘　　要：目的　研究中药鸡血藤 (SpatholobussuberectusDunn)的化学成分。方法　利用多种柱色谱方法进行分离纯化 ,根据光谱数据和化学方法进行结构鉴定。结果　从鸡血藤 70 %乙醇浸膏的乙酸乙酯部分分离鉴定了 8个化合物 ,分别是 :密花豆素 (1)、芒柄花素 (2 )、大豆苷元 (3)、毛蕊异黄酮 (4)、焦性粘液酸 (5 )、间苯三酚 (6 )、琥珀酸 (7)、β 谷甾醇 (8)。结论　化合物 1为 7,3′ ,4′ 三羟基 6 甲氧基二氢黄酮 ,是 1个新化合物 ,命名为密花豆素 ,化合物 4 ,5 ,6和7为首次从本属植物中得到。AIM To study the chemical constituents of Spatholobus suberectus Dunn. METHODS The constituents of Spatholobus suberectus were separated with various chromatographic techniques. The structures were elucidated by physico chemical properties and spectral data. RESULTS Eight compounds were isolated from Spatholobus suberectus Dunn. They were identified as: suberectin (1), formononetin (2), daidzein (3), calycosin (4), pyromucic acid (5), 1,3,5 benzenetriol (6), succinic acid (7) and β sitosterol (8). CONCLUSION Suberectin is a new compound and characterized as 7,3′,4′ trihydroxy 6 methoxy flavanone on the basis of chemical and spectral evidence. Compounds 4, 5, 6 and 7 were obtained from Spatholobus genus for the first time.

关 键 词：鸡血藤 化学成分 二氢黄酮 异黄酮 色谱法 结构鉴定 

分 类 号：R282.71[医药卫生—中药学]