病毒性肠炎、高胃泌素血症与小儿急性肠套叠病因的相互关系  

Viral enteritis and hypergastrinemia in the incidence of acute intussusception in infants

作　　者：宋翠萍[1] 牛爱国[2] 陈莹[1] 

机构地区：[1]河南新乡医学院第一附属医院小儿外科,453100 [2]河北医科大学第二医院小儿外科

出　　处：《中华小儿外科杂志》2002年第5期423-425,共3页Chinese Journal of Pediatric Surgery

摘　　要：目的　研究病毒性肠炎、高胃泌素血症与小儿急性肠套叠病因之间的关系 ,探讨肠套叠的发病原因。方法　对 40例小儿急性肠套叠和 40例病毒性肠炎及对照组 40例正常婴幼儿 ,采用放射免疫法测定其发病不同时期内的血清胃泌素 (Gastrin)和胰高血糖素 (Glucagon)的水平 ,以了解其变化规律。采用乳胶法检测大便中的轮状病毒抗原。结果　与对照组相比 ,病毒性肠炎患儿发病时的血清胃泌素值差异无显著意义 ,而发病后 (3～ 10d)明显增高 (P <0 .0 1) ;小儿急性肠套叠患儿的血清胃泌素值在发病时和发病后 10d、6 0d与对照组相比均差异有显著性意义 ,发病后 90d的胃泌素值与对照组相比无差异 (P >0 .0 1) ;急性肠套叠和病毒性肠炎组的胰高糖素值和对照组相比差异有显著性意义 (P <0 .0 1) ;并且发病后都比发病时的胰高糖素值明显增高。肠套叠大便中轮状病毒的检测率为 5 0 % ,病毒性肠炎均为阳性 ,对照组皆为阴性。Objective To investigate relationship between hypergastrinemia and viral enteritis in the incidence of acute intussusception in infancy. Methods The serum gastrin and glucagon were determined by radioimmunoassy from 40 cases of acute intussusception and 40 cases with viral enteritis. Forty cases were served as control group. Stool rotavirus-antigen was examined by emulsion reaction. Results There was no obvious difference in serum gastric level between the viral enteritis at the onset and the normal. The serum gastric level of viral enteritis appeared significantly higher than that of the normal control 3～10?days later (P< 0.01). There was obvious difference in serum gastric level between acute intussusceptions at the onset, 10 days and 60 days after and the control group. There was no obvious difference in serum gastric level between acute intussusception after 90 days and the normal. The serum glucagon level of viral enteritis and acute intussusception showed apparent difference in the normal control (P< 0.01). The glucagon level was increased progressively in the course of acute intussusception and viral enteritis. The positive rate of stool rotavirus-antigen in intussusception was 50%. All viral enteritis were also positive and control group negative. Conclusions Viral enteritis with hypergastrinemia may be one of the factors leading to acute intussusception in children.

关 键 词：病毒性肠炎 高胃泌素血症 小儿 急性肠套叠 病因 胰高血糖素 放射免疫法 

分 类 号：R726.5[医药卫生—儿科]