头孢匹胺治疗下呼吸道感染的临床疗效  

Clinical efficacy of cefpiramide for lower respiratory tract infection

作　　者：迟春花[1] 何冰[1] 陈尔璋[2] 缪竞智[3] 张洪玉[4] 赵桂荣[1] 曹兆龙[2] 叶静[4] 

机构地区：[1]北京大学第一医院呼吸科,北京100034 [2]北京大学第二医院,北京100044 [3]卫生部北京医院,北京100730 [4]首都医科大学北京朝阳医院,北京100020

出　　处：《中国新药与临床杂志》2002年第10期628-630,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :评价头孢匹胺对下呼吸道感染的临床疗效及安全性。方法 :选择下呼吸道感染病人 4 2例 ,男性 2 7例 ,女性 15例 ,年龄 (6 2±s11)a ,给予头孢匹胺 2 g ,ivbid ,疗程 7～ 10d。结果 :34例病人痰细菌培养阳性 (81% ) ,革兰阴性杆菌占 97% ,β 内酰胺酶阳性率为 6 6 %。经头孢匹胺治疗 ,有效率为74 % ,细菌清除率为 5 6 %。不良反应发生率为 2 %。结论 :头孢匹胺治疗下呼吸道感染是一个安全有效的抗菌药物。AIM: To evaluate the efficacy and safety of cefpiramide in the treatment of lower respiratory tract infection. METHODS: Forty two patients [M 27,F 15;age(62± s 11) a] with lower respiratory tract infection received cefpiramide 2g,iv,gtt bid for 7 10 d. RESULTS: Among forty two patients sputum bacterial culture was positive in thirty four patients (81%) and Gram Negative bacillus 97%.The positive rate of β latamase of pathogenic bacterium was 66%. The effective rate was 74%. Bacterial clearance rate was 56%. The adverse reaction rate was 2%. CONCLUSION: Cefpiramide is an effective and safe antibacterial in the treatment of lower respiratory tract infection.

关 键 词：头孢匹胺 治疗 下呼吸道感染 临床疗效 

分 类 号：R978.11[医药卫生—药品] R56[医药卫生—药学]