系统性红斑狼疮患者外周血淋巴细胞表达BLyS和CD38的变化  

Expression of BLyS and CD38 molecules on peripheral blood lymphocytes of patients with systemic lupus erythematosus

作　　者：张志方[1] 张春艳[2] 周毅[3] 梁柳琴[4] 杨岫岩[4] 张彤[1] 付涌水[4] 潘敬运[1] 

机构地区：[1]中山大学中山医学院生理学教研室,广东广州510089 [2]中山大学中山医学院免疫学教研室,广东广州510089 [3]暨南大学附属华侨医院风湿科,广东广州510632 [4]中山大学附属第一医院风湿科,广东广州510089

出　　处：《中国病理生理杂志》2002年第9期1098-1100,共3页Chinese Journal of Pathophysiology

摘　　要：目的 :研究系统性红斑狼疮 (SLE)患者外周血淋巴细胞表达BLyS和CD38的变化。方法 :收集 2 2名SLE患者和 14名健康人外周血淋巴细胞 ,用流式细胞仪检测外周血淋巴细胞表达BLyS和CD38的变化。结果 :SLE患者外周血BLyS+ 淋巴细胞、CD19+ 淋巴细胞和CD19+ CD38+ 淋巴细胞显著增加 ,BLyS+ 淋巴细胞增加与CD19+CD38+ 淋巴细胞增加呈正相关 (r=0 .4 34,P <0 .0 5 )。结论 :SLE患者外周血淋巴细胞表达BLyS和CD19+ B淋巴细胞表达CD38均显著增加 ,且二者增加呈正相关。AIM: To investigate the expression of B lymphocyte stimulator(BLyS) and CD38 molecules on peripheral blood lymphocytes of patients with systemic lupus erythematosus(SLE). METHODS: Twenty-two patients with SLE and fourteen healthy subjects entered the study. Isolated peripheral blood lymphocyte were stained for the lymphocyte surface markers BLyS, CD19, and CD38, and then was measured by flow cytometry(FACS). RESULTS: BLyS + lymphocytes, CD19 + lymphocytes, and CD19 +CD38 + lymphocytes were increased significantly in patients with SLE( P <0.01, P< 0.01, P< 0.05). The increase in percentage of BLyS + lymphocyted correlated with the increase in percentage of CD19 +CD38 + lymphocytes ( r= 0.043, P< 0.05). CONCLUSION: In patients with SLE, the expression of BLyS on lymphocytes is increased significantly and associated with expression of CD38 on CD19 + B lymphocytes.

关 键 词：系统性红斑狼疮 B淋巴细胞 CD19抗原 CD38抗原 

分 类 号：R593.241[医药卫生—内科学]