卡维地洛、西拉普利及其合用防治大鼠急性心肌梗死左室重塑的作用  

Effects of carvedilol, cilazapril and their combination on left ventricular remodeling after acute myocardial infarction in rats

作　　者：唐熠达[1] 杨跃进[1] 阮英茆[2] 李永利[3] 周燕文[3] 田毅[3] 高润霖[1] 陈纪林[1] 陈在嘉[1] 

机构地区：[1]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院冠心病研究室,北京100037 [2]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院病理科,北京100037 [3]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院实验外科,北京100037

出　　处：《中国病理生理杂志》2002年第9期1115-1118,共4页Chinese Journal of Pathophysiology

摘　　要：目的 :评价卡维地洛、西拉普利及其合用防治大鼠急性心肌梗死 (AMI)左室重塑 (LVRM)的作用。方法 :AMI术后 2 4h存活的 10 0只雌性SD大鼠随机分成 :①AMI对照 (n =2 5 )、②AMI+卡维地洛 (1mg·kg-1·d-1,n =2 5 )、③AMI+西拉普利 (1mg·kg-1·d-1,n =2 5 )及④AMI+合用 (n =2 5 ) 4组 ;另设假手术组 (n =17)。直接灌胃给药。4周后行血流动力学测定和病理学分析。去除梗死面积 <35 %或 >5 5 %者 ,最终在以上各组分别有 (13,12 ,12 ,14 )和13只大鼠。结果 :AMI各组间梗死面积差异均无显著性 (45 .2 % - 4 6 7% ,均P >0 0 5 )。AMI对照组的左室舒张末压(LVEDP)、容积 (LVV)、重量 (LVW)和室间隔厚度 (STh)均显著大于假手术组 (均P <0 0 1) ,左室内压最大上升和下降速率 (±dp/dt)及其校正值 (±dp/dt/LVSP)均显著低于假手术组 (P <0 0 5 ,P <0 0 1)。卡维地洛、西拉普利及合用组的LVEDP、LVV均显著低于AMI对照组 (P <0 0 1) ,STh均显著薄于AMI对照组 (P <0 0 1) ,LVW均显著轻于AMI对照组 (P <0 0 5 ,P <0 0 1) ,±dp/dt显著高于AMI对照组 (P <0 0 5 ,P <0 0 1) ,且LVEDP和STh在合用组显著低于两单用药组 (P <0 0 5 ,P <0 0 1) ,余指标在 3个用药组间差异均无显著性 (均P >0 0 5 )。结论 :?AIM:To compare the effects of carvedilol, cilazapril and their combination on left ventricular remodeling (LVRM) after acute myocardial infarction(AMI) in rats. METHODS: Twenty-four hours after AMI operation, 100 surviving rats were randomly assigned to: ①AMI control ( n= 25), ②AMI+carvedilol (1 mg·kg -1 ·d -1 , n= 25) (C1), ③AMI+cilazapril (1 mg·kg -1 ·d -1 , n= 25) (Z1), and ④ AMI+combination( n= 25) groups. Sham-operated group ( n= 17) were selected randomly. After 4 weeks of therapy with the drugs gastric gavage, hemodynamic and pathological studies were performed. RESULTS: There were no significant differences in MI size among the four AMI groups (all P> 0 05) Left ventricular (LV) end diastolic pressure (LVEDP), volume (LVV), weight (LVW) and septal thickness (STh) were all higher and left ventricular pressure maximal rate of rise and fall (±d p /d t ) were lower (all P< 0 01) in AMI group than sham-operated group. The LVEDP, LVV, LVW and STh were all lower and ±d p /d t were higher in Z1, C1, and combination groups than those in AMI group ( P< 0 05, P< 0 01), with LVEDP and STh were more lower in the combination group than in the two monotherapy group ( P< 0 05, P< 0 01), but there were no significant differences in other variables among the three therapy groups. CONCLUSION: Carvedilol, cilazapril and their combination all can prevent from LVRM after AMI in rats, improve hemodynamics and LV function, with the combination superior.

关 键 词：卡维地洛 西拉普利 心肌梗死 防治 

分 类 号：R542.22[医药卫生—心血管疾病]