强骨抗萎方对尾悬吊大鼠血液流变性影响的观察  

Effects of Qiang Gu Kang Wei Compound on Hemorheology in Tail-suspended Rats.

作　　者：李勇枝[1] 石宏志[1] 范全春[1] 白桂娥[1] 段渊儒[1] 谢俊水[1] 

机构地区：[1]航天医学工程研究所,北京100094

出　　处：《航天医学与医学工程》2002年第5期327-330,共4页Space Medicine & Medical Engineering

基　　金：国家载人航天工程基金资助

摘　　要：目的研究中药复方强骨抗萎方对尾吊大鼠血液流变性的影响。方法用大鼠 5 1只尾吊 - 30° 2 1d模拟失重 ,观察强骨抗萎方对大鼠血沉、红细胞压积、纤维蛋白原、血液粘度及红细胞变形性、聚集性等指标的作用。结果与正常对照组相比 ,悬吊大鼠纤维蛋白原明显升高 (P <0 .0 1 ) ,全血还原粘度及全血粘度明显增加 (P <0 .0 1或P <0 .0 5 ) ,红细胞刚性指数升高 (P <0 .0 1 ) ,最大变形指数降低 (P <0 .0 1 ) ,最大聚集指数增加 (P <0 .0 1 )。该方不同剂量显示了不同的作用。低剂量组 ( 1 0 g/kg)可降低各个切变率下的全血还原粘度和全血粘度 (P <0 .0 1或P <0 .0 5 ) ,以及异常的红细胞刚性指数和最大聚集指数 (P <0 .0 1 ) ;中剂量组 ( 2 0 g/kg)可使纤维蛋白原含量减少 (P <0 .0 1 ) ;高剂量组 ( 30g/kg)可降低高切变率下的全血还原粘度和全血粘度 (P <0 .0 1或P <0 .0 5 ) ,降低红细胞刚性指数 (P <0 .0 1 ) ,并可升高红细胞最大变形指数 (P <0 .0 1 )。结论该方具有改善尾吊大鼠血液流变性的作用 。Objective To investigate the effects of Qiang Gu Kang Wei compound on hemorhelogy in tail suspended rats. Method Rats were tail suspended (-30°) for 21 d to simulate weightlessness. The effect of the compound on erythrocyte sedimentation rate(ESR),hematocrit value(HCT),plasma fibrinogen content(PFC),blood viscosity, red blood cells deformability and erythrocytes aggregation were examined. Result PFC, whole blood reducing viscosity(η h),whole blood viscosity(η b),erythrocyte rigid index(IR) and maximum aggregation index(MAXD) increased significantly(P<0.01 or P<0.05)and maximum deformity index(DI max )(P<0.01) decreased significantly in suspended rats as compared with the normal control. Different doses of the compound showed different effects. The small dose group (10 g/kg)inhabited η h and η b(P< 0.01 or P<0.05) of all shear rates, abnormal IR and MAXD(P<0.01);The middle dose group (20 g/kg)decreased PFC(P<0.01);The big dose group (30 g/kg) inhabited η h and η b(P<0.01 or P<0.05) of high shear rates,decreased IR(P<0.01),and improved DI max (P<0.01).Conclusion This compound could improve hemorhelogy in tail suspended rats. But there was no concentration dependence.

关 键 词：模拟失重 强骨抗萎方 尾部悬吊 血液流变性 血液粘度 变形性 

分 类 号：R852.22[医药卫生—航空、航天与航海医学] R285.5[医药卫生—临床医学]