氧氟沙星中空栓的研制及体外溶出度考察  

Study on the Preparation and in Vitro Dissolubility of Ofloxacin Hollow Suppository

作　　者：景利[1] 曾仁杰[1] 孙伟张[1] 姜云平[1] 王勇[1] 

机构地区：[1]成都军区总医院,成都市610083

出　　处：《中国药房》2002年第10期593-595,共3页China Pharmacy

摘　　要：目的 :制备氧氟沙星中空栓并考察其体外溶出度。方法 :以PEG6000、PEG400、卡波姆为基质 ,蜂蜡为阻滞剂 ,制成中空栓。用一阶导数光谱法测定氧氟沙星中空栓中氧氟沙星的含量。结果 :蜂蜡作为阻滞剂可延缓药物的释放。氧氟沙星中空栓体外溶出呈一级溶出过程 ,k0～1=27 81h-1,显速效 ;k2～6=5 94h-1,显缓释作用。结论 :本制剂工艺可行 ,质量可控 。OBJECTIVE:To prepare ofloxacin hollow suppository(OHS) and to observe its in vitro dissolubility.METHODS:OHS was prepared with PEG 6000,PEG 400 and Carbopol-940 as wase material and wax as retardant.The content of ofloxacin in OHS was determined with the first order derivative UV-spectrophotometry.RESULTS:The wax,as a retardant,could retard the release of drug.The in vitro dissolution of OHS revealed the first order dissolution pattern:K0～1=27.81/h,indicating a speedy effect,K2～6=5.94/h,indicating sustained-release effect.CONCLUSION:This preparation is feasible in technology and controllabe in quality.The preparation of OHS extends the kinds of dose-form of ofloxacin

关 键 词：氧氟沙星 中空栓 体外溶出度 一阶导数光谱法 质量控制 

分 类 号：R927.1[医药卫生—药学]