奥得福尔治疗生殖器疱疹的临床观察  

Clinical Observation on the Safety and Efficacy of Wonderful in the Treatment of Genital Herpes

作　　者：何才偆[1] 石林[2] 宋强 

机构地区：[1]四川省计划生育科学研究所,成都市610041 [2]中国科学院成都生物研究所,成都市610041 [3]四川省生殖健康研究中心,成都市610041

出　　处：《中国药房》2002年第10期606-607,共2页China Pharmacy

基　　金："九五"中国科学院生命科学研究项目 (KZ951-A1-103-04-04);中国科学院地奥科学基金 (DASF)资助项目

摘　　要：目的 :观察黄精多糖制剂奥得福尔治疗生殖器疱疹的临床疗效。方法 :采用随机、开放、平行、对照的方法 ,应用奥得福尔喷剂(WS)和奥得福尔霜剂 (WC) ,同时以阿昔洛韦软膏 (AO)作为对照 ,治疗性病门诊确诊的生殖器疱疹患者5组各80例 (共400例 ) ,观察临床疗效及其不良反应。结果 :WS开放组的总有效率为92 50 % ,平行组为91 25 % ;WC开放组的总有效率为93 75 % ,平行组为91 25 %。WS组 (开放组 +平行组 )在3天内起效的达64 38 % ,7天内起效的达91 88 % ;WC组 (开放组 +平行组 )在3天内起效的达68 13 % ,7天内起效的达91 88 % ;两者起效时间平均比AO组提前2天。所有病例均无严重不良反应 ,患者依从性好。结论 :奥得福尔治疗生殖器疱疹起效快、疗程短、疗效显著 ,且应用方便。OBJECTIVE:To assess clinical efficacy and safety of Wonderful(W),a preparation of polysaccharides of rhizoma polygonati,in the treatment of genital herpes(GH).METHODS:In a random,open,parallel and controlled design,400 cases of GH were divided into 5 groups(each group 80 cases):open W spray(WS) group,open W cream(WC) group,parallel WS group,parallel WC group and control group(aciclovir ointment AO).The therapeutic efficacy and ADRs were observed.RESULTS:The total effective rates of open WS group,parallel WS group,open WC group and parallel WC group were 92.50%,91.25%,93.75% and 91.25% respectively.Effects showed in 64.38% of cases treated with WS(open+parallel) and 68.13% of cases treated with WC within 3 days and 91.88% and 91.88% within 7 days.The initiation of effect of W was 2 days earlier than that of AO.No serious ADRs were found and the patients' compliance was good.CONCLUSION:W is rapid in initiation of efficacy,short in therapeutic course,satisfactory in effect,convenient in application and safe.

关 键 词：奥得福尔 治疗 生殖器疱疹 临床观察 黄精多糖 

分 类 号：R277.571.6[医药卫生—中医学] R285.6